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Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells.
Sikkema AH, de Bont ES, Molema G, Dimberg A, Zwiers PJ, Diks SH, Hoving EW, Kamps WA, Peppelenbosch MP, den Dunnen WF. Sikkema AH, et al. Among authors: den dunnen wf. Neuropathol Appl Neurobiol. 2011 Aug;37(5):538-48. doi: 10.1111/j.1365-2990.2011.01160.x. Neuropathol Appl Neurobiol. 2011. PMID: 21208252
Kinome profiling in pediatric brain tumors as a new approach for target discovery.
Sikkema AH, Diks SH, den Dunnen WF, ter Elst A, Scherpen FJ, Hoving EW, Ruijtenbeek R, Boender PJ, de Wijn R, Kamps WA, Peppelenbosch MP, de Bont ES. Sikkema AH, et al. Among authors: den dunnen wf. Cancer Res. 2009 Jul 15;69(14):5987-95. doi: 10.1158/0008-5472.CAN-08-3660. Epub 2009 Jun 30. Cancer Res. 2009. PMID: 19567681
EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion.
Sikkema AH, den Dunnen WF, Hulleman E, van Vuurden DG, Garcia-Manero G, Yang H, Scherpen FJ, Kampen KR, Hoving EW, Kamps WA, Diks SH, Peppelenbosch MP, de Bont ES. Sikkema AH, et al. Among authors: den dunnen wf. Neuro Oncol. 2012 Sep;14(9):1125-35. doi: 10.1093/neuonc/nos130. Epub 2012 Jun 21. Neuro Oncol. 2012. PMID: 22723427 Free PMC article.
Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma.
Sie M, den Dunnen WF, Lourens HJ, Meeuwsen-de Boer TG, Scherpen FJ, Zomerman WW, Kampen KR, Hoving EW, de Bont ES. Sie M, et al. Among authors: den dunnen wf. PLoS One. 2015 Mar 23;10(3):e0122555. doi: 10.1371/journal.pone.0122555. eCollection 2015. PLoS One. 2015. PMID: 25799134 Free PMC article.
Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma.
Zomerman WW, Plasschaert SLA, Conroy S, Scherpen FJ, Meeuwsen-de Boer TGJ, Lourens HJ, Guerrero Llobet S, Smit MJ, Slagter-Menkema L, Seitz A, Gidding CEM, Hulleman E, Wesseling P, Meijer L, van Kempen LC, van den Berg A, Warmerdam DO, Kruyt FAE, Foijer F, van Vugt MATM, den Dunnen WFA, Hoving EW, Guryev V, de Bont ESJM, Bruggeman SWM. Zomerman WW, et al. Cell Rep. 2018 Mar 20;22(12):3206-3216. doi: 10.1016/j.celrep.2018.02.089. Cell Rep. 2018. PMID: 29562177 Free article.
175 results