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Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.
Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN. Kienlen-Campard P, et al. Among authors: constantinescu sn. J Biol Chem. 2008 Mar 21;283(12):7733-44. doi: 10.1074/jbc.M707142200. Epub 2008 Jan 16. J Biol Chem. 2008. PMID: 18201969 Free PMC article.
A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.
Sato T, Tang TC, Reubins G, Fei JZ, Fujimoto T, Kienlen-Campard P, Constantinescu SN, Octave JN, Aimoto S, Smith SO. Sato T, et al. Among authors: constantinescu sn. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1421-6. doi: 10.1073/pnas.0812261106. Epub 2009 Jan 21. Proc Natl Acad Sci U S A. 2009. PMID: 19164538 Free PMC article.
What is the role of amyloid precursor protein dimerization?
Khalifa NB, Van Hees J, Tasiaux B, Huysseune S, Smith SO, Constantinescu SN, Octave JN, Kienlen-Campard P. Khalifa NB, et al. Among authors: constantinescu sn. Cell Adh Migr. 2010 Apr-Jun;4(2):268-72. doi: 10.4161/cam.4.2.11476. Epub 2010 Apr 11. Cell Adh Migr. 2010. PMID: 20400860 Free PMC article.
658 results