Tinker A - Search Results

1

K+ channels in the heart: new insights and therapeutic implications.

Tinker A, Harmer SC. Tinker A, et al. Expert Rev Clin Pharmacol. 2010 May;3(3):305-19. doi: 10.1586/ecp.10.14. Expert Rev Clin Pharmacol. 2010. PMID: 22111612

2

The role of abnormal trafficking of KCNE1 in long QT syndrome 5.

Harmer SC, Tinker A. Harmer SC, et al. Among authors: tinker a. Biochem Soc Trans. 2007 Nov;35(Pt 5):1074-6. doi: 10.1042/BST0351074. Biochem Soc Trans. 2007. PMID: 17956282 Review.

3

Mechanisms of disease pathogenesis in long QT syndrome type 5.

Harmer SC, Wilson AJ, Aldridge R, Tinker A. Harmer SC, et al. Among authors: tinker a. Am J Physiol Cell Physiol. 2010 Feb;298(2):C263-73. doi: 10.1152/ajpcell.00308.2009. Epub 2009 Nov 11. Am J Physiol Cell Physiol. 2010. PMID: 19907016 Free PMC article.

4

Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.

Mashanov GI, Nobles M, Harmer SC, Molloy JE, Tinker A. Mashanov GI, et al. Among authors: tinker a. J Biol Chem. 2010 Feb 5;285(6):3664-3675. doi: 10.1074/jbc.M109.039974. Epub 2009 Nov 23. J Biol Chem. 2010. PMID: 19940153 Free PMC article.

5

Characterization of a binding site for anionic phospholipids on KCNQ1.

Thomas AM, Harmer SC, Khambra T, Tinker A. Thomas AM, et al. Among authors: tinker a. J Biol Chem. 2011 Jan 21;286(3):2088-100. doi: 10.1074/jbc.M110.153551. Epub 2010 Nov 17. J Biol Chem. 2011. PMID: 21084310 Free PMC article.

6

Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations.

Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A, Ellard S, Hussain K. Kapoor RR, et al. Among authors: tinker a. Diabetologia. 2011 Oct;54(10):2575-83. doi: 10.1007/s00125-011-2207-4. Epub 2011 Jun 15. Diabetologia. 2011. PMID: 21674179 Free PMC article.

7

Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel.

Harmer SC, Mohal JS, Kemp D, Tinker A. Harmer SC, et al. Among authors: tinker a. Biochem J. 2012 May 1;443(3):635-42. doi: 10.1042/BJ20111912. Biochem J. 2012. PMID: 22309168

8

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂.

Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA. Telezhkin V, et al. Among authors: tinker a. Pflugers Arch. 2013 Jul;465(7):945-53. doi: 10.1007/s00424-012-1199-3. Epub 2013 Jan 6. Pflugers Arch. 2013. PMID: 23291709 Free PMC article.

9

Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1.

Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD, Tinker A. Harmer SC, et al. Among authors: tinker a. Biochem J. 2014 Aug 15;462(1):133-42. doi: 10.1042/BJ20140425. Biochem J. 2014. PMID: 24912595

10

Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8.

Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A, Hussain K. Nessa A, et al. Among authors: tinker a. Hum Mol Genet. 2015 Sep 15;24(18):5142-53. doi: 10.1093/hmg/ddv233. Epub 2015 Jun 19. Hum Mol Genet. 2015. PMID: 26092864

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