Wesolowski GA - Search Results

1

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys.

Masarachia PJ, Pennypacker BL, Pickarski M, Scott KR, Wesolowski GA, Smith SY, Samadfam R, Goetzmann JE, Scott BB, Kimmel DB, Duong LT. Masarachia PJ, et al. Among authors: wesolowski ga. J Bone Miner Res. 2012 Mar;27(3):509-23. doi: 10.1002/jbmr.1475. J Bone Miner Res. 2012. PMID: 22113859 Free article.

2

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.

Hayami T, Zhuo Y, Wesolowski GA, Pickarski M, Duong LT. Hayami T, et al. Among authors: wesolowski ga. Bone. 2012 Jun;50(6):1250-9. doi: 10.1016/j.bone.2012.03.025. Epub 2012 Mar 30. Bone. 2012. PMID: 22484689

3

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model.

Hayami T, Pickarski M, Wesolowski GA, McLane J, Bone A, Destefano J, Rodan GA, Duong LT. Hayami T, et al. Among authors: wesolowski ga. Arthritis Rheum. 2004 Apr;50(4):1193-206. doi: 10.1002/art.20124. Arthritis Rheum. 2004. PMID: 15077302 Free article.

4

Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis.

Coleman PJ, Brashear KM, Askew BC, Hutchinson JH, McVean CA, Duong LT, Feuston BP, Fernandez-Metzler C, Gentile MA, Hartman GD, Kimmel DB, Leu CT, Lipfert L, Merkle K, Pennypacker B, Prueksaritanont T, Rodan GA, Wesolowski GA, Rodan SB, Duggan ME. Coleman PJ, et al. Among authors: wesolowski ga. J Med Chem. 2004 Sep 23;47(20):4829-37. doi: 10.1021/jm049874c. J Med Chem. 2004. PMID: 15369386

5

Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.

Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, Duong LT. Hayami T, et al. Among authors: wesolowski ga. Bone. 2006 Feb;38(2):234-43. doi: 10.1016/j.bone.2005.08.007. Epub 2005 Sep 26. Bone. 2006. PMID: 16185945

6

Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis.

Ma B, Luo B, Euler DH, Cusick TE, Wesolowski G, Glantschnig H, Duong LT, Ou Y, Carroll SS, Lubbers LS. Ma B, et al. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):435-441. doi: 10.1007/s00210-017-1356-5. Epub 2017 Feb 20. Naunyn Schmiedebergs Arch Pharmacol. 2017. PMID: 28220210 Clinical Trial.

7

Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis.

Duong LT, Wesolowski GA, Leung P, Oballa R, Pickarski M. Duong LT, et al. Among authors: wesolowski ga. Mol Cancer Ther. 2014 Dec;13(12):2898-909. doi: 10.1158/1535-7163.MCT-14-0253. Epub 2014 Sep 23. Mol Cancer Ther. 2014. PMID: 25249554

8

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong LT, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T, Li CS, Massé F, McKay DJ, Nicoll-Griffith DA, Oballa RM, Palmer JT, Percival MD, Riendeau D, Robichaud J, Rodan GA, Rodan SB, Seto C, Thérien M, Truong VL, Venuti MC, Wesolowski G, Young RN, Zamboni R, Black WC. Gauthier JY, et al. Among authors: wesolowski g. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8. doi: 10.1016/j.bmcl.2007.12.047. Epub 2008 Jan 15. Bioorg Med Chem Lett. 2008. PMID: 18226527

9

M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts.

Elsegood CL, Zhuo Y, Wesolowski GA, Hamilton JA, Rodan GA, Duong LT. Elsegood CL, et al. Among authors: wesolowski ga. Int J Biochem Cell Biol. 2006;38(9):1518-29. doi: 10.1016/j.biocel.2006.02.011. Epub 2006 Mar 2. Int J Biochem Cell Biol. 2006. PMID: 16600665

10

Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/Ort mouse.

Watters JW, Cheng C, Pickarski M, Wesolowski GA, Zhuo Y, Hayami T, Wang W, Szumiloski J, Phillips RL, Duong LT. Watters JW, et al. Among authors: wesolowski ga. Arthritis Rheum. 2007 Sep;56(9):2999-3009. doi: 10.1002/art.22836. Arthritis Rheum. 2007. PMID: 17763422 Free article.

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