Darke PL - Search Results

1

Characterization of an active single polypeptide form of the human immunodeficiency virus type 1 protease.

DiIanni CL, Davis LJ, Holloway MK, Herber WK, Darke PL, Kohl NE, Dixon RA. DiIanni CL, et al. Among authors: darke pl. J Biol Chem. 1990 Oct 5;265(28):17348-54. J Biol Chem. 1990. PMID: 2211628 Free article.

2

Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.

Fitzgerald PM, McKeever BM, VanMiddlesworth JF, Springer JP, Heimbach JC, Leu CT, Herber WK, Dixon RA, Darke PL. Fitzgerald PM, et al. Among authors: darke pl. J Biol Chem. 1990 Aug 25;265(24):14209-19. J Biol Chem. 1990. PMID: 2201682 Free article.

3

Human immunodeficiency virus protease. Bacterial expression and characterization of the purified aspartic protease.

Darke PL, Leu CT, Davis LJ, Heimbach JC, Diehl RE, Hill WS, Dixon RA, Sigal IS. Darke PL, et al. J Biol Chem. 1989 Feb 5;264(4):2307-12. J Biol Chem. 1989. PMID: 2644259 Free article.

4

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1.

Navia MA, Fitzgerald PM, McKeever BM, Leu CT, Heimbach JC, Herber WK, Sigal IS, Darke PL, Springer JP. Navia MA, et al. Among authors: darke pl. Nature. 1989 Feb 16;337(6208):615-20. doi: 10.1038/337615a0. Nature. 1989. PMID: 2645523

5

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.

Thompson WJ, Fitzgerald PM, Holloway MK, Emini EA, Darke PL, McKeever BM, Schleif WA, Quintero JC, Zugay JA, Tucker TJ, et al. Thompson WJ, et al. Among authors: darke pl. J Med Chem. 1992 May 15;35(10):1685-701. doi: 10.1021/jm00088a003. J Med Chem. 1992. PMID: 1588551

6

Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.

Darke PL, Kohl NE, Hanobik MG, Leu CT, Vacca JP, Guare JP, Heimbach JC, Dixon RA. Darke PL, et al. Adv Exp Med Biol. 1991;306:483-7. doi: 10.1007/978-1-4684-6012-4_61. Adv Exp Med Biol. 1991. PMID: 1812746 No abstract available.

7

Affinity purification of the HIV-1 protease.

Heimbach JC, Garsky VM, Michelson SR, Dixon RA, Sigal IS, Darke PL. Heimbach JC, et al. Among authors: darke pl. Biochem Biophys Res Commun. 1989 Nov 15;164(3):955-60. doi: 10.1016/0006-291x(89)91762-2. Biochem Biophys Res Commun. 1989. PMID: 2686642

8

The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Lee HY, Thompson WJ, Culberson C, Holloway MK, McKee SP, Munson PM, Duong TT, Smith AM, Darke PL, et al. Ghosh AK, et al. Among authors: darke pl. J Med Chem. 1994 Apr 15;37(8):1177-88. doi: 10.1021/jm00034a016. J Med Chem. 1994. PMID: 8164260

9

Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Ghosh AK, Thompson WJ, Holloway MK, McKee SP, Duong TT, Lee HY, Munson PM, Smith AM, Wai JM, Darke PL, et al. Ghosh AK, et al. Among authors: darke pl. J Med Chem. 1993 Aug 6;36(16):2300-10. doi: 10.1021/jm00068a006. J Med Chem. 1993. PMID: 8360874

10

Activity and dimerization of human immunodeficiency virus protease as a function of solvent composition and enzyme concentration.

Jordan SP, Zugay J, Darke PL, Kuo LC. Jordan SP, et al. Among authors: darke pl. J Biol Chem. 1992 Oct 5;267(28):20028-32. J Biol Chem. 1992. PMID: 1400318 Free article.

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