Breyholz HJ - Search Results

1

A new generation of radiofluorinated pyrimidine-2,4,6-triones as MMP-targeted radiotracers for positron emission tomography.

Schrigten D, Breyholz HJ, Wagner S, Hermann S, Schober O, Schäfers M, Haufe G, Kopka K. Schrigten D, et al. Among authors: breyholz hj. J Med Chem. 2012 Jan 12;55(1):223-32. doi: 10.1021/jm201142w. Epub 2011 Dec 13. J Med Chem. 2012. PMID: 22118188

2

Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo.

Kopka K, Breyholz HJ, Wagner S, Law MP, Riemann B, Schröer S, Trub M, Guilbert B, Levkau B, Schober O, Schäfers M. Kopka K, et al. Among authors: breyholz hj. Nucl Med Biol. 2004 Feb;31(2):257-67. doi: 10.1016/j.nucmedbio.2003.08.003. Nucl Med Biol. 2004. PMID: 15013492

3

Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo.

Schäfers M, Riemann B, Kopka K, Breyholz HJ, Wagner S, Schäfers KP, Law MP, Schober O, Levkau B. Schäfers M, et al. Among authors: breyholz hj. Circulation. 2004 Jun 1;109(21):2554-9. doi: 10.1161/01.CIR.0000129088.49276.83. Epub 2004 May 3. Circulation. 2004. PMID: 15123523

4

C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging.

Breyholz HJ, Schäfers M, Wagner S, Höltke C, Faust A, Rabeneck H, Levkau B, Schober O, Kopka K. Breyholz HJ, et al. J Med Chem. 2005 May 5;48(9):3400-9. doi: 10.1021/jm049145x. J Med Chem. 2005. PMID: 15857146

5

Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ET(A) receptor radioligands.

Höltke C, Law MP, Wagner S, Breyholz HJ, Kopka K, Bremer C, Levkau B, Schober O, Schäfers M. Höltke C, et al. Among authors: breyholz hj. Bioorg Med Chem. 2006 Mar 15;14(6):1910-7. doi: 10.1016/j.bmc.2005.10.039. Epub 2005 Nov 10. Bioorg Med Chem. 2006. PMID: 16289856

6

5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.

Kopka K, Faust A, Keul P, Wagner S, Breyholz HJ, Höltke C, Schober O, Schäfers M, Levkau B. Kopka K, et al. Among authors: breyholz hj. J Med Chem. 2006 Nov 16;49(23):6704-15. doi: 10.1021/jm051217c. J Med Chem. 2006. PMID: 17154501

7

Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET.

Wagner S, Breyholz HJ, Law MP, Faust A, Höltke C, Schröer S, Haufe G, Levkau B, Schober O, Schäfers M, Kopka K. Wagner S, et al. Among authors: breyholz hj. J Med Chem. 2007 Nov 15;50(23):5752-64. doi: 10.1021/jm0708533. Epub 2007 Oct 23. J Med Chem. 2007. PMID: 17956082

8

Synthesis and evaluation of a novel fluorescent photoprobe for imaging matrix metalloproteinases.

Faust A, Waschkau B, Waldeck J, Höltke C, Breyholz HJ, Wagner S, Kopka K, Heindel W, Schäfers M, Bremer C. Faust A, et al. Among authors: breyholz hj. Bioconjug Chem. 2008 May;19(5):1001-8. doi: 10.1021/bc700409j. Epub 2008 Apr 9. Bioconjug Chem. 2008. PMID: 18396900

9

A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies.

Wagner S, Breyholz HJ, Höltke C, Faust A, Schober O, Schäfers M, Kopka K. Wagner S, et al. Among authors: breyholz hj. Appl Radiat Isot. 2009 Apr;67(4):606-10. doi: 10.1016/j.apradiso.2008.12.009. Epub 2008 Dec 24. Appl Radiat Isot. 2009. PMID: 19167232

10

Synthesis and evaluation of a novel hydroxamate based fluorescent photoprobe for imaging of matrix metalloproteinases.

Faust A, Waschkau B, Waldeck J, Höltke C, Breyholz HJ, Wagner S, Kopka K, Schober O, Heindel W, Schäfers M, Bremer C. Faust A, et al. Among authors: breyholz hj. Bioconjug Chem. 2009 May 20;20(5):904-12. doi: 10.1021/bc8004478. Bioconjug Chem. 2009. PMID: 19374404

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