Shetty B - Search Results

1

Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models.

Yamazaki S, Vicini P, Shen Z, Zou HY, Lee J, Li Q, Christensen JG, Smith BJ, Shetty B. Yamazaki S, et al. Among authors: shetty b. J Pharmacol Exp Ther. 2012 Mar;340(3):549-57. doi: 10.1124/jpet.111.188870. Epub 2011 Nov 30. J Pharmacol Exp Ther. 2012. PMID: 22129595

2

Discovery pharmacokinetic studies in mice using serial microsampling, dried blood spots and microbore LC-MS/MS.

Rahavendran SV, Vekich S, Skor H, Batugo M, Nguyen L, Shetty B, Shen Z. Rahavendran SV, et al. Among authors: shetty b. Bioanalysis. 2012 May;4(9):1077-95. doi: 10.4155/bio.12.85. Bioanalysis. 2012. PMID: 22612688

3

AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies.

Webber S, Bartlett CA, Boritzki TJ, Hillard JA, Howland EF, Johnston AL, Kosa M, Margosiak SA, Morse CA, Shetty BV. Webber S, et al. Among authors: shetty bv. Cancer Chemother Pharmacol. 1996;37(6):509-17. doi: 10.1007/s002800050422. Cancer Chemother Pharmacol. 1996. PMID: 8612303

4

Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia.

Burns-Naas LA, Zorbas M, Jessen B, Evering W, Stevens G, Ivett JL, Ryan TE, Cook JC, Capen CC, Chen M, Furman G, Theiss JC, Webber S, Wu E, Shetty B, Gasser R, McClain RM. Burns-Naas LA, et al. Among authors: shetty b. Hum Exp Toxicol. 2005 Dec;24(12):643-54. doi: 10.1191/0960327105ht568oa. Hum Exp Toxicol. 2005. PMID: 16408618

5

Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease.

Shetty BV, Kosa MB, Khalil DA, Webber S. Shetty BV, et al. Antimicrob Agents Chemother. 1996 Jan;40(1):110-4. doi: 10.1128/AAC.40.1.110. Antimicrob Agents Chemother. 1996. PMID: 8787890 Free PMC article.

6

Phase I study of AG 331, a novel thymidylate synthase inhibitor, in patients with refractory solid tumors.

Koda RT, Garcia AA, Chatterjee DJ, Li WY, Parimoo D, Jeffers S, Rogers M, Leichman CG, Leichman L, Wu EY, Shetty BV, Webber S, Clendinnin N, Muggia FM. Koda RT, et al. Among authors: shetty bv. Cancer Chemother Pharmacol. 1999;43(6):489-96. doi: 10.1007/s002800050928. Cancer Chemother Pharmacol. 1999. PMID: 10321509 Clinical Trial.

7

A unique example of drug metabolism: tetra- and penta-oxygenation reactions of capravirine in rats, dogs and humans.

Bu HZ, Pool WF, Wu EY, Shetty BV. Bu HZ, et al. Drug Metab Lett. 2007 Jan;1(1):61-5. doi: 10.2174/187231207779814373. Drug Metab Lett. 2007. PMID: 19356020

8

Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design.

Melnick M, Reich SH, Lewis KK, Mitchell LJ Jr, Nguyen D, Trippe AJ, Dawson H, Davies JF 2nd, Appelt K, Wu BW, Musick L, Gehlhaar DK, Webber S, Shetty B, Kosa M, Kahil D, Andrada D. Melnick M, et al. Among authors: shetty b. J Med Chem. 1996 Jul 5;39(14):2795-811. doi: 10.1021/jm960092w. J Med Chem. 1996. PMID: 8709110

9

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.

Kaldor SW, Kalish VJ, Davies JF 2nd, Shetty BV, Fritz JE, Appelt K, Burgess JA, Campanale KM, Chirgadze NY, Clawson DK, Dressman BA, Hatch SD, Khalil DA, Kosa MB, Lubbehusen PP, Muesing MA, Patick AK, Reich SH, Su KS, Tatlock JH. Kaldor SW, et al. Among authors: shetty bv. J Med Chem. 1997 Nov 21;40(24):3979-85. doi: 10.1021/jm9704098. J Med Chem. 1997. PMID: 9397180

10

Characterization of the selectivity and mechanism of human cytochrome P450 inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate.

Lillibridge JH, Liang BH, Kerr BM, Webber S, Quart B, Shetty BV, Lee CA. Lillibridge JH, et al. Among authors: shetty bv. Drug Metab Dispos. 1998 Jul;26(7):609-16. Drug Metab Dispos. 1998. PMID: 9660842

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