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Natural killer cell differentiation from hematopoietic stem cells: a comparative analysis of heparin- and stromal cell-supported methods.
Dezell SA, Ahn YO, Spanholtz J, Wang H, Weeres M, Jackson S, Cooley S, Dolstra H, Miller JS, Verneris MR. Dezell SA, et al. Among authors: spanholtz j. Biol Blood Marrow Transplant. 2012 Apr;18(4):536-45. doi: 10.1016/j.bbmt.2011.11.023. Epub 2011 Dec 7. Biol Blood Marrow Transplant. 2012. PMID: 22155502 Free PMC article.
Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells.
Lehmann D, Spanholtz J, Osl M, Tordoir M, Lipnik K, Bilban M, Schlechta B, Dolstra H, Hofer E. Lehmann D, et al. Among authors: spanholtz j. Stem Cells Dev. 2012 Nov 1;21(16):2926-38. doi: 10.1089/scd.2011.0659. Epub 2012 Jul 17. Stem Cells Dev. 2012. PMID: 22571679 Free PMC article.
Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice.
Cany J, van der Waart AB, Tordoir M, Franssen GM, Hangalapura BN, de Vries J, Boerman O, Schaap N, van der Voort R, Spanholtz J, Dolstra H. Cany J, et al. Among authors: spanholtz j. PLoS One. 2013 Jun 5;8(6):e64384. doi: 10.1371/journal.pone.0064384. Print 2013. PLoS One. 2013. PMID: 23755121 Free PMC article.
The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells.
Thordardottir S, Hangalapura BN, Hutten T, Cossu M, Spanholtz J, Schaap N, Radstake TR, van der Voort R, Dolstra H. Thordardottir S, et al. Among authors: spanholtz j. Stem Cells Dev. 2014 May 1;23(9):955-67. doi: 10.1089/scd.2013.0521. Epub 2014 Jan 24. Stem Cells Dev. 2014. PMID: 24325394 Clinical Trial.
Combined IL-15 and IL-12 drives the generation of CD34+-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer.
Cany J, van der Waart AB, Spanholtz J, Tordoir M, Jansen JH, van der Voort R, Schaap NM, Dolstra H. Cany J, et al. Among authors: spanholtz j. Oncoimmunology. 2015 Apr 1;4(7):e1017701. doi: 10.1080/2162402X.2015.1017701. eCollection 2015 Jul. Oncoimmunology. 2015. PMID: 26140247 Free PMC article.
35 results