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5-HT(2B) receptors are required for serotonin-selective antidepressant actions.
Diaz SL, Doly S, Narboux-Nême N, Fernández S, Mazot P, Banas SM, Boutourlinsky K, Moutkine I, Belmer A, Roumier A, Maroteaux L. Diaz SL, et al. Among authors: roumier a. Mol Psychiatry. 2012 Feb;17(2):154-63. doi: 10.1038/mp.2011.159. Epub 2011 Dec 13. Mol Psychiatry. 2012. PMID: 22158014 Free PMC article.
Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.
Danglot L, Freret T, Le Roux N, Narboux Nême N, Burgo A, Hyenne V, Roumier A, Contremoulins V, Dauphin F, Bizot JC, Vodjdani G, Gaspar P, Boulouard M, Poncer JC, Galli T, Simmler MC. Danglot L, et al. Among authors: roumier a. J Neurosci. 2012 Jun 27;32(26):9007-22. doi: 10.1523/JNEUROSCI.3084-11.2012. J Neurosci. 2012. PMID: 22745500 Free PMC article.
Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis.
El Oussini H, Bayer H, Scekic-Zahirovic J, Vercruysse P, Sinniger J, Dirrig-Grosch S, Dieterlé S, Echaniz-Laguna A, Larmet Y, Müller K, Weishaupt JH, Thal DR, van Rheenen W, van Eijk K, Lawson R, Monassier L, Maroteaux L, Roumier A, Wong PC, van den Berg LH, Ludolph AC, Veldink JH, Witting A, Dupuis L. El Oussini H, et al. Among authors: roumier a. Acta Neuropathol. 2016 Mar;131(3):465-80. doi: 10.1007/s00401-016-1534-4. Epub 2016 Jan 7. Acta Neuropathol. 2016. PMID: 26744351 Free article.
Positive regulation of raphe serotonin neurons by serotonin 2B receptors.
Belmer A, Quentin E, Diaz SL, Guiard BP, Fernandez SP, Doly S, Banas SM, Pitychoutis PM, Moutkine I, Muzerelle A, Tchenio A, Roumier A, Mameli M, Maroteaux L. Belmer A, et al. Among authors: roumier a. Neuropsychopharmacology. 2018 Jun;43(7):1623-1632. doi: 10.1038/s41386-018-0013-0. Epub 2018 Feb 5. Neuropsychopharmacology. 2018. PMID: 29453444 Free PMC article.
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.
Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D. Barnes NM, et al. Among authors: roumier a. Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. Pharmacol Rev. 2021. PMID: 33370241 Free PMC article. Review.
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