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An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.
Donnelly PS, Liddell JR, Lim S, Paterson BM, Cater MA, Savva MS, Mot AI, James JL, Trounce IA, White AR, Crouch PJ. Donnelly PS, et al. Among authors: savva ms. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):47-52. doi: 10.1073/pnas.1116227108. Epub 2011 Dec 15. Proc Natl Acad Sci U S A. 2012. PMID: 22173633 Free PMC article.
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
Crouch PJ, Savva MS, Hung LW, Donnelly PS, Mot AI, Parker SJ, Greenough MA, Volitakis I, Adlard PA, Cherny RA, Masters CL, Bush AI, Barnham KJ, White AR. Crouch PJ, et al. Among authors: savva ms. J Neurochem. 2011 Oct;119(1):220-30. doi: 10.1111/j.1471-4159.2011.07402.x. Epub 2011 Aug 25. J Neurochem. 2011. PMID: 21797865 Free article.