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Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids.
Gögebakan Ö, Andres J, Biedasek K, Mai K, Kühnen P, Krude H, Isken F, Rudovich N, Osterhoff MA, Kintscher U, Nauck M, Pfeiffer AF, Spranger J. Gögebakan Ö, et al. Among authors: kuhnen p. Diabetes. 2012 Feb;61(2):292-300. doi: 10.2337/db10-0902. Epub 2011 Dec 16. Diabetes. 2012. PMID: 22179810 Free PMC article. Clinical Trial.
New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.
Biebermann H, Winkler F, Handke D, Teichmann A, Gerling B, Cameron F, Eichhorst J, Grüters A, Wiesner B, Kühnen P, Krude H, Kleinau G. Biebermann H, et al. Among authors: kuhnen p. J Clin Endocrinol Metab. 2012 Feb;97(2):E228-32. doi: 10.1210/jc.2011-2106. Epub 2011 Nov 23. J Clin Endocrinol Metab. 2012. PMID: 22112806
Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.
Kühnen P, Handke D, Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Grötzinger C, Gromoll J, Wiegand S, Grüters A, Krude H. Kühnen P, et al. Cell Metab. 2016 Sep 13;24(3):502-509. doi: 10.1016/j.cmet.2016.08.001. Epub 2016 Aug 25. Cell Metab. 2016. PMID: 27568547 Free article.
Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1.
Mühlhaus J, Dinter J, Jyrch S, Teumer A, Jacobi SF, Homuth G, Kühnen P, Wiegand S, Grüters A, Völzke H, Raile K, Kleinau G, Krude H, Biebermann H. Mühlhaus J, et al. Among authors: kuhnen p. Front Pharmacol. 2017 Nov 24;8:807. doi: 10.3389/fphar.2017.00807. eCollection 2017. Front Pharmacol. 2017. PMID: 29225575 Free PMC article.
Mean High-Dose l-Thyroxine Treatment Is Efficient and Safe to Achieve a Normal IQ in Young Adult Patients With Congenital Hypothyroidism.
Aleksander PE, Brückner-Spieler M, Stoehr AM, Lankes E, Kühnen P, Schnabel D, Ernert A, Stäblein W, Craig ME, Blankenstein O, Grüters A, Krude H. Aleksander PE, et al. Among authors: kuhnen p. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1459-1469. doi: 10.1210/jc.2017-01937. J Clin Endocrinol Metab. 2018. PMID: 29325045
64 results