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IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes.
Bochud PY, Bibert S, Kutalik Z, Patin E, Guergnon J, Nalpas B, Goossens N, Kuske L, Müllhaupt B, Gerlach T, Heim MH, Moradpour D, Cerny A, Malinverni R, Regenass S, Dollenmaier G, Hirsch H, Martinetti G, Gorgiewski M, Bourlière M, Poynard T, Theodorou I, Abel L, Pol S, Dufour JF, Negro F; Swiss Hepatitis C Cohort Study Group; ANRS HC EP 26 Genoscan Study Group. Bochud PY, et al. Among authors: malinverni r. Hepatology. 2012 Feb;55(2):384-94. doi: 10.1002/hep.24678. Epub 2011 Dec 16. Hepatology. 2012. PMID: 22180014
Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C.
Bochud PY, Cai T, Overbeck K, Bochud M, Dufour JF, Müllhaupt B, Borovicka J, Heim M, Moradpour D, Cerny A, Malinverni R, Francioli P, Negro F; Swiss Hepatitis C Cohort Study Group. Bochud PY, et al. Among authors: malinverni r. J Hepatol. 2009 Oct;51(4):655-66. doi: 10.1016/j.jhep.2009.05.016. Epub 2009 Jun 6. J Hepatol. 2009. PMID: 19665246
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.
Rauch A, Kutalik Z, Descombes P, Cai T, Di Iulio J, Mueller T, Bochud M, Battegay M, Bernasconi E, Borovicka J, Colombo S, Cerny A, Dufour JF, Furrer H, Günthard HF, Heim M, Hirschel B, Malinverni R, Moradpour D, Müllhaupt B, Witteck A, Beckmann JS, Berg T, Bergmann S, Negro F, Telenti A, Bochud PY; Swiss Hepatitis C Cohort Study; Swiss HIV Cohort Study. Rauch A, et al. Among authors: malinverni r. Gastroenterology. 2010 Apr;138(4):1338-45, 1345.e1-7. doi: 10.1053/j.gastro.2009.12.056. Epub 2010 Jan 11. Gastroenterology. 2010. PMID: 20060832
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
Lange CM, Kutalik Z, Morikawa K, Bibert S, Cerny A, Dollenmaier G, Dufour JF, Gerlach TJ, Heim MH, Malinverni R, Müllhaupt B, Negro F, Moradpour D, Bochud PY; Swiss Hepatitis C Cohort Study Group. Lange CM, et al. Among authors: malinverni r. Hepatology. 2012 Apr;55(4):1038-47. doi: 10.1002/hep.24787. Epub 2012 Feb 9. Hepatology. 2012. PMID: 22095909
A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.
Lange CM, Bibert S, Kutalik Z, Burgisser P, Cerny A, Dufour JF, Geier A, Gerlach TJ, Heim MH, Malinverni R, Negro F, Regenass S, Badenhoop K, Bojunga J, Sarrazin C, Zeuzem S, Müller T, Berg T, Bochud PY, Moradpour D; Swiss Hepatitis C Cohort Study Group. Lange CM, et al. Among authors: malinverni r. PLoS One. 2012;7(7):e40159. doi: 10.1371/journal.pone.0040159. Epub 2012 Jul 12. PLoS One. 2012. PMID: 22808108 Free PMC article.
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.
Patin E, Kutalik Z, Guergnon J, Bibert S, Nalpas B, Jouanguy E, Munteanu M, Bousquet L, Argiro L, Halfon P, Boland A, Müllhaupt B, Semela D, Dufour JF, Heim MH, Moradpour D, Cerny A, Malinverni R, Hirsch H, Martinetti G, Suppiah V, Stewart G, Booth DR, George J, Casanova JL, Bréchot C, Rice CM, Talal AH, Jacobson IM, Bourlière M, Theodorou I, Poynard T, Negro F, Pol S, Bochud PY, Abel L; Swiss Hepatitis C Cohort Study Group, International Hepatitis C Genetics Consortium; French ANRS HC EP 26 Genoscan Study Group. Patin E, et al. Among authors: malinverni r. Gastroenterology. 2012 Nov;143(5):1244-1252.e12. doi: 10.1053/j.gastro.2012.07.097. Epub 2012 Jul 27. Gastroenterology. 2012. PMID: 22841784 Free PMC article.
Comparative genetic analyses point to HCP5 as susceptibility locus for HCV-associated hepatocellular carcinoma.
Lange CM, Bibert S, Dufour JF, Cellerai C, Cerny A, Heim MH, Kaiser L, Malinverni R, Müllhaupt B, Negro F, Semela D, Moradpour D, Kutalik Z, Bochud PY; Swiss Hepatitis C Cohort Study Group. Lange CM, et al. Among authors: malinverni r. J Hepatol. 2013 Sep;59(3):504-9. doi: 10.1016/j.jhep.2013.04.032. Epub 2013 May 9. J Hepatol. 2013. PMID: 23665287
IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction.
Bibert S, Roger T, Calandra T, Bochud M, Cerny A, Semmo N, Duong FH, Gerlach T, Malinverni R, Moradpour D, Negro F, Müllhaupt B, Bochud PY; Swiss Hepatitis C Cohort Study. Bibert S, et al. Among authors: malinverni r. J Exp Med. 2013 Jun 3;210(6):1109-16. doi: 10.1084/jem.20130012. Epub 2013 May 27. J Exp Med. 2013. PMID: 23712427 Free PMC article.
140 results