Schade D - Search Results

1

Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response.

Lanier M, Schade D, Willems E, Tsuda M, Spiering S, Kalisiak J, Mercola M, Cashman JR. Lanier M, et al. Among authors: schade d. J Med Chem. 2012 Jan 26;55(2):697-708. doi: 10.1021/jm2010223. Epub 2012 Jan 13. J Med Chem. 2012. PMID: 22191557 Free PMC article.

2

Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

Kotthaus J, Schade D, Muschick N, Beitz E, Clement B. Kotthaus J, et al. Among authors: schade d. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. doi: 10.1016/j.bmc.2008.10.058. Epub 2008 Oct 29. Bioorg Med Chem. 2008. PMID: 19013076

3

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. Willems E, et al. Among authors: schade d. Cell Stem Cell. 2012 Aug 3;11(2):242-52. doi: 10.1016/j.stem.2012.04.025. Cell Stem Cell. 2012. PMID: 22862949 Free PMC article.

4

Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR. Schade D, et al. J Med Chem. 2012 Nov 26;55(22):9946-57. doi: 10.1021/jm301144g. Epub 2012 Nov 6. J Med Chem. 2012. PMID: 23130626 Free PMC article.

5

Small molecules targeting in vivo tissue regeneration.

Längle D, Halver J, Rathmer B, Willems E, Schade D. Längle D, et al. Among authors: schade d. ACS Chem Biol. 2014 Jan 17;9(1):57-71. doi: 10.1021/cb4008277. Epub 2014 Jan 6. ACS Chem Biol. 2014. PMID: 24372447 Review.

6

Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ/Smad inhibitors.

Längle D, Marquardt V, Heider E, Vigante B, Duburs G, Luntena I, Flötgen D, Golz C, Strohmann C, Koch O, Schade D. Längle D, et al. Among authors: schade d. Eur J Med Chem. 2015 May 5;95:249-66. doi: 10.1016/j.ejmech.2015.03.027. Epub 2015 Mar 14. Eur J Med Chem. 2015. PMID: 25817775

7

Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?

Halver J, Wenzel K, Sendker J, Carrillo García C, Erdelmeier CAJ, Willems E, Mercola M, Symma N, Könemann S, Koch E, Hensel A, Schade D. Halver J, et al. Among authors: schade d. Front Pharmacol. 2019 Nov 27;10:1357. doi: 10.3389/fphar.2019.01357. eCollection 2019. Front Pharmacol. 2019. PMID: 31849643 Free PMC article.

8

Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness.

Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway PJ, Colas AR, Lancman JJ, Schade D, Perea-Gil I, Bruyneel AAN, Lee J, Vadgama N, Quach J, McKeithan WL, Biechele TL, Wu JC, Moon RT, Si Dong PD, Karakikes I, Cashman JR, Mercola M. Cheng J, et al. Among authors: schade d. Cell Chem Biol. 2021 May 20;28(5):625-635.e5. doi: 10.1016/j.chembiol.2021.01.001. Epub 2021 Jan 26. Cell Chem Biol. 2021. PMID: 33503403 Free PMC article.

9

Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase.

Kotthaus J, Schade D, Kotthaus J, Clement B. Kotthaus J, et al. Among authors: schade d. J Enzyme Inhib Med Chem. 2012 Feb;27(1):24-8. doi: 10.3109/14756366.2011.573480. Epub 2011 Jul 8. J Enzyme Inhib Med Chem. 2012. PMID: 21740101 Free article.

10

Medicinal Chemistry Approaches to Heart Regeneration.

Schade D, Plowright AT. Schade D, et al. J Med Chem. 2015 Dec 24;58(24):9451-79. doi: 10.1021/acs.jmedchem.5b00446. Epub 2015 Sep 3. J Med Chem. 2015. PMID: 26288266 Review.

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