Ghelardini C - Search Results

1

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.

Catalano A, Desaphy JF, Lentini G, Carocci A, Di Mola A, Bruno C, Carbonara R, De Palma A, Budriesi R, Ghelardini C, Perrone MG, Colabufo NA, Conte Camerino D, Franchini C. Catalano A, et al. Among authors: ghelardini c. J Med Chem. 2012 Feb 9;55(3):1418-22. doi: 10.1021/jm201197z. Epub 2012 Jan 31. J Med Chem. 2012. PMID: 22191686

2

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters.

Gualtieri F, Conti G, Dei S, Giovannoni MP, Nannucci F, Romanelli MN, Scapecchi S, Teodori E, Fanfani L, Ghelardini C, et al. Gualtieri F, et al. Among authors: ghelardini c. J Med Chem. 1994 May 27;37(11):1704-11. doi: 10.1021/jm00037a022. J Med Chem. 1994. PMID: 8201605

3

Stereoselectivity in central analgesic action of tocainide and its analogs.

Franchini C, Noja FC, Corbo F, Lentini G, Tortorella V, Bartolini A, Ghelardini C, Matucci R, Giotti A. Franchini C, et al. Among authors: ghelardini c. Chirality. 1993;5(3):135-42. doi: 10.1002/chir.530050306. Chirality. 1993. PMID: 8338723

4

Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.

Manetti D, Ghelardini C, Bartolini A, Bellucci C, Dei S, Galeotti N, Gualtieri F, Romanelli MN, Scapecchi S, Teodori E. Manetti D, et al. Among authors: ghelardini c. J Med Chem. 2000 May 18;43(10):1969-74. doi: 10.1021/jm991170t. J Med Chem. 2000. PMID: 10821709

5

Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.

Melchiorre C, Bolognesi ML, Budriesi R, Ghelardini C, Chiarini A, Minarini A, Rosini M, Tumiatti V, Wade EJ. Melchiorre C, et al. Among authors: ghelardini c. J Med Chem. 2001 Nov 22;44(24):4035-8. doi: 10.1021/jm0155594. J Med Chem. 2001. PMID: 11708906

6

Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities.

Cappelli A, Anzini M, Vomero S, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Giorgi G, Ghelardini C, Collina S. Cappelli A, et al. Among authors: ghelardini c. Bioorg Med Chem. 2002 Mar;10(3):779-801. doi: 10.1016/s0968-0896(01)00332-7. Bioorg Med Chem. 2002. PMID: 11814868

7

Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.

Anzini M, Canullo L, Braile C, Cappelli A, Gallelli A, Vomero S, Menziani MC, De Benedetti PG, Rizzo M, Collina S, Azzolina O, Sbacchi M, Ghelardini C, Galeotti N. Anzini M, et al. Among authors: ghelardini c. J Med Chem. 2003 Aug 28;46(18):3853-64. doi: 10.1021/jm0307640. J Med Chem. 2003. PMID: 12930147

8

Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.

Teodori E, Baldi E, Dei S, Gualtieri F, Romanelli MN, Scapecchi S, Bellucci C, Ghelardini C, Matucci R. Teodori E, et al. Among authors: ghelardini c. J Med Chem. 2004 Nov 18;47(24):6070-81. doi: 10.1021/jm049923l. J Med Chem. 2004. PMID: 15537361

9

Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent.

Martini E, Ghelardini C, Bertucci C, Dei S, Gualtieri F, Guandalini L, Manetti D, Scapecchi S, Teodori E, Romanelli MN. Martini E, et al. Among authors: ghelardini c. Med Chem. 2005 Sep;1(5):473-80. doi: 10.2174/1573406054864142. Med Chem. 2005. PMID: 16787332

10

Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.

Colotta V, Catarzi D, Varano F, Lenzi O, Filacchioni G, Costagli C, Galli A, Ghelardini C, Galeotti N, Gratteri P, Sgrignani J, Deflorian F, Moro S. Colotta V, et al. Among authors: ghelardini c. J Med Chem. 2006 Oct 5;49(20):6015-26. doi: 10.1021/jm0604880. J Med Chem. 2006. PMID: 17004715

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