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Page 1
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Pfefferkorn JA, Guzman-Perez A, Litchfield J, Aiello R, Treadway JL, Pettersen J, Minich ML, Filipski KJ, Jones CS, Tu M, Aspnes G, Risley H, Bian J, Stevens BD, Bourassa P, D'Aquila T, Baker L, Barucci N, Robertson AS, Bourbonais F, Derksen DR, Macdougall M, Cabrera O, Chen J, Lapworth AL, Landro JA, Zavadoski WJ, Atkinson K, Haddish-Berhane N, Tan B, Yao L, Kosa RE, Varma MV, Feng B, Duignan DB, El-Kattan A, Murdande S, Liu S, Ammirati M, Knafels J, Dasilva-Jardine P, Sweet L, Liras S, Rolph TP. Pfefferkorn JA, et al. Among authors: baker l. J Med Chem. 2012 Feb 9;55(3):1318-33. doi: 10.1021/jm2014887. Epub 2012 Jan 24. J Med Chem. 2012. PMID: 22196621
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Pfefferkorn JA, Tu M, Filipski KJ, Guzman-Perez A, Bian J, Aspnes GE, Sammons MF, Song W, Li JC, Jones CS, Patel L, Rasmusson T, Zeng D, Karki K, Hamilton M, Hank R, Atkinson K, Litchfield J, Aiello R, Baker L, Barucci N, Bourassa P, Bourbonais F, D'Aquila T, Derksen DR, MacDougall M, Robertson A. Pfefferkorn JA, et al. Among authors: baker l. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7100-5. doi: 10.1016/j.bmcl.2012.09.082. Epub 2012 Sep 29. Bioorg Med Chem Lett. 2012. PMID: 23089526
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.
Erion DM, Lapworth A, Amor PA, Bai G, Vera NB, Clark RW, Yan Q, Zhu Y, Ross TT, Purkal J, Gorgoglione M, Zhang G, Bonato V, Baker L, Barucci N, D'Aquila T, Robertson A, Aiello RJ, Yan J, Trimmer J, Rolph TP, Pfefferkorn JA. Erion DM, et al. Among authors: baker l. PLoS One. 2014 May 23;9(5):e97139. doi: 10.1371/journal.pone.0097139. eCollection 2014. PLoS One. 2014. PMID: 24858947 Free PMC article.
Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project).
Udeh-Momoh CT, Maina R, Anazodo UC, Akinyemi R, Atwoli L, Baker L, Bassil D, Blackmon K, Bosire E, Chemutai G, Crivelli L, Eze LU, Ibanez A, Kafetsouli D, Karikari TK, Khakali L, Kumar M, Lengyel I, de Jager Loots CA, Mangialasche F, Mbugua S, Merali Z, Mielke M, Mostert C, Muthoni E, Nesic-Taylor O, Ngugi A, Nguku S, Ogunniyi A, Ogunyemi A, Okonkwo OC, Okubadejo N, Perneczky R, Peto T, Riang'a RM, Saleh M, Sayed S, Shah J, Shah S, Solomon A, Thesen T, Trepel D, Ucheagwu V, Valcour V, Waa S, Watermeyer T, Yokoyama J, Zetterberg H, Kivipelto M; Africa‐FINGERS Study Team. Udeh-Momoh CT, et al. Among authors: baker l. Alzheimers Dement. 2024 Nov 7. doi: 10.1002/alz.14344. Online ahead of print. Alzheimers Dement. 2024. PMID: 39511921
Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
Vasas A, Ivanschitz L, Molnár B, Kiss Á, Baker L, Fiumana A, Macias A, Murray JB, Sanders E, Whitehead N, Hubbard RE, Saunier C, Monceau E, Girard AM, Rousseau M, Chanrion M, Demarles D, Geneste O, Weber C, Lewkowicz E, Kotschy A. Vasas A, et al. Among authors: baker l. J Med Chem. 2024 Oct 23. doi: 10.1021/acs.jmedchem.4c01472. Online ahead of print. J Med Chem. 2024. PMID: 39441669
2,983 results