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Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.
Ranta F, Leveringhaus J, Theilig D, Schulz-Raffelt G, Hennige AM, Hildebrand DG, Handrick R, Jendrossek V, Bosch F, Schulze-Osthoff K, Häring HU, Ullrich S. Ranta F, et al. Among authors: hennige am. PLoS One. 2011;6(12):e28828. doi: 10.1371/journal.pone.0028828. Epub 2011 Dec 27. PLoS One. 2011. PMID: 22216119 Free PMC article.
The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal.
Weigert C, Hennige AM, Brischmann T, Beck A, Moeschel K, Schaüble M, Brodbeck K, Häring HU, Schleicher ED, Lehmann R. Weigert C, et al. Among authors: hennige am. J Biol Chem. 2005 Nov 11;280(45):37393-9. doi: 10.1074/jbc.M506134200. Epub 2005 Aug 29. J Biol Chem. 2005. PMID: 16129678 Free article.
81 results