Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Sanders JM, Song Y, Chan JM, Zhang Y, Jennings S, Kosztowski T, Odeh S, Flessner R, Schwerdtfeger C, Kotsikorou E, Meints GA, Gómez AO, González-Pacanowska D, Raker AM, Wang H, van Beek ER, Papapoulos SE, Morita CT, Oldfield E.
Sanders JM, et al. Among authors: morita ct.
J Med Chem. 2005 Apr 21;48(8):2957-63. doi: 10.1021/jm040209d.
J Med Chem. 2005.
PMID: 15828834