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Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress.
Vladykovskaya E, Sithu SD, Haberzettl P, Wickramasinghe NS, Merchant ML, Hill BG, McCracken J, Agarwal A, Dougherty S, Gordon SA, Schuschke DA, Barski OA, O'Toole T, D'Souza SE, Bhatnagar A, Srivastava S. Vladykovskaya E, et al. J Biol Chem. 2012 Mar 30;287(14):11398-409. doi: 10.1074/jbc.M111.320416. Epub 2012 Jan 6. J Biol Chem. 2012. PMID: 22228760 Free PMC article.
Environmental risk factors for heart disease.
O'Toole TE, Conklin DJ, Bhatnagar A. O'Toole TE, et al. Rev Environ Health. 2008 Jul-Sep;23(3):167-202. doi: 10.1515/reveh.2008.23.3.167. Rev Environ Health. 2008. PMID: 19119685 Review.
Exposure to acrolein by inhalation causes platelet activation.
Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ, Haberzettl P, O'Toole TE, Bhatnagar A, D'Souza SE. Sithu SD, et al. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):100-10. doi: 10.1016/j.taap.2010.07.013. Epub 2010 Aug 3. Toxicol Appl Pharmacol. 2010. PMID: 20678513 Free PMC article.
Acrolein exposure is associated with increased cardiovascular disease risk.
DeJarnett N, Conklin DJ, Riggs DW, Myers JA, O'Toole TE, Hamzeh I, Wagner S, Chugh A, Ramos KS, Srivastava S, Higdon D, Tollerud DJ, DeFilippis A, Becher C, Wyatt B, McCracken J, Abplanalp W, Rai SN, Ciszewski T, Xie Z, Yeager R, Prabhu SD, Bhatnagar A. DeJarnett N, et al. J Am Heart Assoc. 2014 Aug 6;3(4):e000934. doi: 10.1161/JAHA.114.000934. J Am Heart Assoc. 2014. PMID: 25099132 Free PMC article.
333 results