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Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML.
Hirabayashi S, Flotho C, Moetter J, Heuser M, Hasle H, Gruhn B, Klingebiel T, Thol F, Schlegelberger B, Baumann I, Strahm B, Stary J, Locatelli F, Zecca M, Bergstraesser E, Dworzak M, van den Heuvel-Eibrink MM, De Moerloose B, Ogawa S, Niemeyer CM, Wlodarski MW; European Working Group of MDS in Childhood. Hirabayashi S, et al. Among authors: flotho c. Blood. 2012 Mar 15;119(11):e96-9. doi: 10.1182/blood-2011-12-395087. Epub 2012 Jan 11. Blood. 2012. PMID: 22238327 Free article.
Mucinous cystadenoma of the ovary in a 15-year-old girl.
Flotho C, Rückauer K, Duffner U, Bergstässer E, Böhm N, Niemeyer CM. Flotho C, et al. J Pediatr Surg. 2001 Jun;36(6):E6. doi: 10.1053/jpsu.2001.24019. J Pediatr Surg. 2001. PMID: 11381449 Review.
Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia.
Kratz CP, Niemeyer CM, Thomas C, Bauhuber S, Matejas V, Bergsträsser E, Flotho C, Flores NJ, Haas O, Hasle H, van den Heuvel-Eibrink MM, Kucherlapati RS, Lang P, Roberts AE, Starý J, Strahm B, Swanson KD, Trebo M, Zecca M, Neel B, Locatelli F, Loh ML, Zenker M. Kratz CP, et al. Among authors: flotho c. Leukemia. 2007 May;21(5):1108-9. doi: 10.1038/sj.leu.2404620. Epub 2007 Feb 22. Leukemia. 2007. PMID: 17315019 No abstract available.
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.
Flotho C, Steinemann D, Mullighan CG, Neale G, Mayer K, Kratz CP, Schlegelberger B, Downing JR, Niemeyer CM. Flotho C, et al. Oncogene. 2007 Aug 23;26(39):5816-21. doi: 10.1038/sj.onc.1210361. Epub 2007 Mar 12. Oncogene. 2007. PMID: 17353900
88 results