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Page 1
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier.
Wang L, Cherian C, Kugel Desmoulin S, Mitchell-Ryan S, Hou Z, Matherly LH, Gangjee A. Wang L, et al. Among authors: mitchell ryan s. J Med Chem. 2012 Feb 23;55(4):1758-70. doi: 10.1021/jm201688n. Epub 2012 Feb 3. J Med Chem. 2012. PMID: 22243528 Free PMC article.
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.
Wang L, Desmoulin SK, Cherian C, Polin L, White K, Kushner J, Fulterer A, Chang MH, Mitchell-Ryan S, Stout M, Romero MF, Hou Z, Matherly LH, Gangjee A. Wang L, et al. J Med Chem. 2011 Oct 27;54(20):7150-64. doi: 10.1021/jm200739e. Epub 2011 Sep 22. J Med Chem. 2011. PMID: 21879757 Free PMC article.
Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Wang Y, Cherian C, Orr S, Mitchell-Ryan S, Hou Z, Raghavan S, Matherly LH, Gangjee A. Wang Y, et al. Among authors: mitchell ryan s. J Med Chem. 2013 Nov 14;56(21):8684-95. doi: 10.1021/jm401139z. Epub 2013 Oct 30. J Med Chem. 2013. PMID: 24111942 Free PMC article.
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity.
Mitchell-Ryan S, Wang Y, Raghavan S, Ravindra MP, Hales E, Orr S, Cherian C, Hou Z, Matherly LH, Gangjee A. Mitchell-Ryan S, et al. J Med Chem. 2013 Dec 27;56(24):10016-10032. doi: 10.1021/jm401328u. Epub 2013 Dec 11. J Med Chem. 2013. PMID: 24256410 Free PMC article.
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.
Wang Y, Mitchell-Ryan S, Raghavan S, George C, Orr S, Hou Z, Matherly LH, Gangjee A. Wang Y, et al. Among authors: mitchell ryan s. J Med Chem. 2015 Feb 12;58(3):1479-93. doi: 10.1021/jm501787c. Epub 2015 Feb 2. J Med Chem. 2015. PMID: 25602637 Free PMC article.
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
Wang L, Wallace A, Raghavan S, Deis SM, Wilson MR, Yang S, Polin L, White K, Kushner J, Orr S, George C, O'Connor C, Hou Z, Mitchell-Ryan S, Dann CE 3rd, Matherly LH, Gangjee A. Wang L, et al. Among authors: mitchell ryan s. J Med Chem. 2015 Sep 10;58(17):6938-59. doi: 10.1021/acs.jmedchem.5b00801. Epub 2015 Aug 28. J Med Chem. 2015. PMID: 26317331 Free PMC article.
Review of dose setting for the extended one-generation reproductive toxicity studies (OECD TG 443): Considerations on ECHA's dose level selection recommendations.
Beekhuijzen M, Richmond E, Manton J, Coder PS, Goyak K, Ghaffari R, Makris SL, Van Cruchten S, Zorrilla L, Mitchell-Ryan S. Beekhuijzen M, et al. Among authors: mitchell ryan s. Regul Toxicol Pharmacol. 2024 Aug;151:105665. doi: 10.1016/j.yrtph.2024.105665. Epub 2024 Jun 15. Regul Toxicol Pharmacol. 2024. PMID: 38885874 Free article. Review.
Current approaches to evaluate the function of cytotoxic T-cells in non-human primates.
Kamperschroer C, Frank B, Genell C, Lebrec H, Mitchell-Ryan S, Molinier B, Newsome C, Piche MS, Weinstock D, Collinge M, Freebern W, Rubio D. Kamperschroer C, et al. Among authors: mitchell ryan s. J Immunotoxicol. 2023 Dec;20(1):2176952. doi: 10.1080/1547691X.2023.2176952. J Immunotoxicol. 2023. PMID: 36788724 Free article. Review.
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