Chen H - Search Results

1

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody.

Chu SY, Horton HM, Pong E, Leung IW, Chen H, Nguyen DH, Bautista C, Muchhal US, Bernett MJ, Moore GL, Szymkowski DE, Desjarlais JR. Chu SY, et al. Among authors: chen h. J Allergy Clin Immunol. 2012 Apr;129(4):1102-15. doi: 10.1016/j.jaci.2011.11.029. Epub 2012 Jan 16. J Allergy Clin Immunol. 2012. PMID: 22257644

2

Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions.

Moore GL, Chen H, Karki S, Lazar GA. Moore GL, et al. Among authors: chen h. MAbs. 2010 Mar-Apr;2(2):181-9. doi: 10.4161/mabs.2.2.11158. MAbs. 2010. PMID: 20150767 Free PMC article.

3

Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies.

Horton HM, Bernett MJ, Peipp M, Pong E, Karki S, Chu SY, Richards JO, Chen H, Repp R, Desjarlais JR, Zhukovsky EA. Horton HM, et al. Among authors: chen h. Blood. 2010 Oct 21;116(16):3004-12. doi: 10.1182/blood-2010-01-265280. Epub 2010 Jul 8. Blood. 2010. PMID: 20616215 Free article.

4

Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn.

Bernett MJ, Chu SY, Leung I, Moore GL, Lee SH, Pong E, Chen H, Phung S, Muchhal US, Horton HM, Lazar GA, Desjarlais JR, Szymkowski DE. Bernett MJ, et al. Among authors: chen h. MAbs. 2013 May-Jun;5(3):384-96. doi: 10.4161/mabs.23976. Epub 2013 Apr 2. MAbs. 2013. PMID: 23549103 Free PMC article.

5

Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor.

Chu SY, Yeter K, Kotha R, Pong E, Miranda Y, Phung S, Chen H, Lee SH, Leung I, Bonzon C, Desjarlais JR, Stohl W, Szymkowski DE. Chu SY, et al. Among authors: chen h. Arthritis Rheumatol. 2014 May;66(5):1153-64. doi: 10.1002/art.38334. Arthritis Rheumatol. 2014. PMID: 24782179

6

Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells.

Richards JO, Karki S, Lazar GA, Chen H, Dang W, Desjarlais JR. Richards JO, et al. Among authors: chen h. Mol Cancer Ther. 2008 Aug;7(8):2517-27. doi: 10.1158/1535-7163.MCT-08-0201. Mol Cancer Ther. 2008. PMID: 18723496

7

Engineering fully human monoclonal antibodies from murine variable regions.

Bernett MJ, Karki S, Moore GL, Leung IW, Chen H, Pong E, Nguyen DH, Jacinto J, Zalevsky J, Muchhal US, Desjarlais JR, Lazar GA. Bernett MJ, et al. Among authors: chen h. J Mol Biol. 2010 Mar 12;396(5):1474-90. doi: 10.1016/j.jmb.2009.12.046. Epub 2010 Jan 4. J Mol Biol. 2010. PMID: 20045416

8

Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.

Tai YT, Horton HM, Kong SY, Pong E, Chen H, Cemerski S, Bernett MJ, Nguyen DH, Karki S, Chu SY, Lazar GA, Munshi NC, Desjarlais JR, Anderson KC, Muchhal US. Tai YT, et al. Among authors: chen h. Blood. 2012 Mar 1;119(9):2074-82. doi: 10.1182/blood-2011-06-364521. Epub 2012 Jan 13. Blood. 2012. PMID: 22246035 Free PMC article.

9

Efficacy and safety of olverembatinib as maintenance therapy after allogeneic hematopoietic cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Kong J, Zheng FM, Yan CH, Wang JZ, Fu HX, Wang ZD, Suo P, Hu GH, Lv M, Chen H, Mo XD, Xu LP, Zhang XH, Huang XJ, Wang Y. Kong J, et al. Among authors: chen h. Ann Hematol. 2025 Jan 16. doi: 10.1007/s00277-025-06198-0. Online ahead of print. Ann Hematol. 2025. PMID: 39815121

10

The highly conserved PIWI-interacting RNA CRAPIR antagonizes PA2G4-mediated NF110-NF45 disassembly to promote heart regeneration in mice.

Ma W, Chen H, Tian Y, Huang W, Ren Z, Li J, Ouyang Q, Hu Y, Wang X, Ji H, Liu X, Liu Y, Wang X, Liu Y, Tian Y, Li F, Yang B, Wang N, Cai B. Ma W, et al. Among authors: chen h. Nat Cardiovasc Res. 2025 Jan 15. doi: 10.1038/s44161-024-00592-z. Online ahead of print. Nat Cardiovasc Res. 2025. PMID: 39814981

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