Schoenfelder A - Search Results

1

Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.

Solinas A, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Mann A, Manetti F, Taddei M, Ruat M. Solinas A, et al. Among authors: schoenfelder a. J Med Chem. 2012 Feb 23;55(4):1559-71. doi: 10.1021/jm2013369. Epub 2012 Feb 10. J Med Chem. 2012. PMID: 22268551

2

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.

Hoch L, Faure H, Roudaut H, Schoenfelder A, Mann A, Girard N, Bihannic L, Ayrault O, Petricci E, Taddei M, Rognan D, Ruat M. Hoch L, et al. Among authors: schoenfelder a. FASEB J. 2015 May;29(5):1817-29. doi: 10.1096/fj.14-267849. Epub 2015 Jan 30. FASEB J. 2015. PMID: 25636740 Free PMC article.

3

Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.

Manetti F, Faure H, Roudaut H, Gorojankina T, Traiffort E, Schoenfelder A, Mann A, Solinas A, Taddei M, Ruat M. Manetti F, et al. Among authors: schoenfelder a. Mol Pharmacol. 2010 Oct;78(4):658-65. doi: 10.1124/mol.110.065102. Epub 2010 Jul 27. Mol Pharmacol. 2010. PMID: 20664000

4

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.

Roudaut H, Traiffort E, Gorojankina T, Vincent L, Faure H, Schoenfelder A, Mann A, Manetti F, Solinas A, Taddei M, Ruat M. Roudaut H, et al. Among authors: schoenfelder a. Mol Pharmacol. 2011 Mar;79(3):453-60. doi: 10.1124/mol.110.069708. Epub 2010 Dec 21. Mol Pharmacol. 2011. PMID: 21177415

5

Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.

Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M. Gorojankina T, et al. Among authors: schoenfelder a. Mol Pharmacol. 2013 May;83(5):1020-9. doi: 10.1124/mol.112.084590. Epub 2013 Feb 28. Mol Pharmacol. 2013. PMID: 23448715

6

Stereoselective multicomponent assembly of enantiopure oxazolopiperidines and -azepines.

Zill N, Schoenfelder A, Girard N, Taddei M, Mann A. Zill N, et al. Among authors: schoenfelder a. J Org Chem. 2012 Mar 2;77(5):2246-53. doi: 10.1021/jo202455c. Epub 2012 Feb 13. J Org Chem. 2012. PMID: 22283333

7

Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.

Masdeu C, Faure H, Coulombe J, Schoenfelder A, Mann A, Brabet I, Pin JP, Traiffort E, Ruat M. Masdeu C, et al. Among authors: schoenfelder a. Biochem Biophys Res Commun. 2006 Oct 20;349(2):471-9. doi: 10.1016/j.bbrc.2006.07.216. Epub 2006 Aug 22. Biochem Biophys Res Commun. 2006. PMID: 16945339

8

Microwaves make hydroformylation a rapid and easy process.

Petricci E, Mann A, Schoenfelder A, Rota A, Taddei M. Petricci E, et al. Among authors: schoenfelder a. Org Lett. 2006 Aug 17;8(17):3725-7. doi: 10.1021/ol061312v. Org Lett. 2006. PMID: 16898802

9

(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase.

Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD. Wermuth CG, et al. Among authors: schoenfelder a. J Med Chem. 1996 Feb 16;39(4):814-6. doi: 10.1021/jm9508144. J Med Chem. 1996. PMID: 8632404 No abstract available.

10

A general approach to aza-heterocycles by means of domino sequences driven by hydroformylation.

Airiau E, Spangenberg T, Girard N, Schoenfelder A, Salvadori J, Taddei M, Mann A. Airiau E, et al. Among authors: schoenfelder a. Chemistry. 2008;14(35):10938-48. doi: 10.1002/chem.200801795. Chemistry. 2008. PMID: 19009576

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