Neklesa TK - Search Results

1

Identification of hydrophobic tags for the degradation of stabilized proteins.

Tae HS, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM. Tae HS, et al. Among authors: neklesa tk. Chembiochem. 2012 Mar 5;13(4):538-41. doi: 10.1002/cbic.201100793. Epub 2012 Jan 23. Chembiochem. 2012. PMID: 22271667 Free PMC article.

2

Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.

Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM. Neklesa TK, et al. Nat Chem Biol. 2011 Jul 3;7(8):538-43. doi: 10.1038/nchembio.597. Nat Chem Biol. 2011. PMID: 21725302 Free PMC article.

3

A bidirectional system for the dynamic small molecule control of intracellular fusion proteins.

Neklesa TK, Noblin DJ, Kuzin AP, Lew S, Seetharaman J, Acton TB, Kornhaber GJ, Xiao R, Montelione GT, Tong L, Crews CM. Neklesa TK, et al. ACS Chem Biol. 2013 Oct 18;8(10):2293-2300. doi: 10.1021/cb400569k. Epub 2013 Aug 26. ACS Chem Biol. 2013. PMID: 23978068 Free PMC article.

4

Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.

Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Gustafson JL, et al. Among authors: neklesa tk. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9659-62. doi: 10.1002/anie.201503720. Epub 2015 Jun 17. Angew Chem Int Ed Engl. 2015. PMID: 26083457 Free PMC article.

5

Chemical biology: Greasy tags for protein removal.

Neklesa TK, Crews CM. Neklesa TK, et al. Nature. 2012 Jul 18;487(7407):308-9. doi: 10.1038/487308a. Nature. 2012. PMID: 22810693 No abstract available.

6

Targeted protein degradation by PROTACs.

Neklesa TK, Winkler JD, Crews CM. Neklesa TK, et al. Pharmacol Ther. 2017 Jun;174:138-144. doi: 10.1016/j.pharmthera.2017.02.027. Epub 2017 Feb 14. Pharmacol Ther. 2017. PMID: 28223226 Review.

7

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance.

Salami J, Alabi S, Willard RR, Vitale NJ, Wang J, Dong H, Jin M, McDonnell DP, Crew AP, Neklesa TK, Crews CM. Salami J, et al. Among authors: neklesa tk. Commun Biol. 2018 Aug 2;1:100. doi: 10.1038/s42003-018-0105-8. eCollection 2018. Commun Biol. 2018. PMID: 30271980 Free PMC article.

8

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.

Crew AP, Raina K, Dong H, Qian Y, Wang J, Vigil D, Serebrenik YV, Hamman BD, Morgan A, Ferraro C, Siu K, Neklesa TK, Winkler JD, Coleman KG, Crews CM. Crew AP, et al. Among authors: neklesa tk. J Med Chem. 2018 Jan 25;61(2):583-598. doi: 10.1021/acs.jmedchem.7b00635. Epub 2017 Jul 10. J Med Chem. 2018. PMID: 28692295

9

Increased transcription and high translation efficiency lead to accumulation of androgen receptor splice variant after androgen deprivation therapy.

Ma T, Bai S, Qi Y, Zhan Y, Ungerleider N, Zhang DY, Neklesa T, Corey E, Dehm SM, Zhang K, Flemington EK, Dong Y. Ma T, et al. Cancer Lett. 2021 Apr 28;504:37-48. doi: 10.1016/j.canlet.2020.12.037. Epub 2021 Feb 6. Cancer Lett. 2021. PMID: 33556543 Free PMC article.

10

Targeting Nuclear Receptors with PROTAC degraders.

Flanagan JJ, Neklesa TK. Flanagan JJ, et al. Among authors: neklesa tk. Mol Cell Endocrinol. 2019 Aug 1;493:110452. doi: 10.1016/j.mce.2019.110452. Epub 2019 May 21. Mol Cell Endocrinol. 2019. PMID: 31125586 Review.

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