Savas U - Search Results

1

Crystal structure of human cytochrome P450 2D6 with prinomastat bound.

Wang A, Savas U, Hsu MH, Stout CD, Johnson EF. Wang A, et al. Among authors: savas u. J Biol Chem. 2012 Mar 30;287(14):10834-43. doi: 10.1074/jbc.M111.307918. Epub 2012 Feb 3. J Biol Chem. 2012. PMID: 22308038 Free PMC article.

2

Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.

Hsu MH, Savas U, Griffin KJ, Johnson EF. Hsu MH, et al. Among authors: savas u. J Biol Chem. 2007 Feb 23;282(8):5225-36. doi: 10.1074/jbc.M608176200. Epub 2006 Dec 1. J Biol Chem. 2007. PMID: 17142457 Free article.

3

Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation.

Hsu MH, Savas U, Griffin KJ, Johnson EF. Hsu MH, et al. Among authors: savas u. Drug Metab Rev. 2007;39(2-3):515-38. doi: 10.1080/03602530701468573. Drug Metab Rev. 2007. PMID: 17786636 Review.

4

Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model.

Savas Ü, Machemer DEW, Hsu MH, Gaynor P, Lasker JM, Tukey RH, Johnson EF. Savas Ü, et al. J Biol Chem. 2009 Jun 12;284(24):16541-16552. doi: 10.1074/jbc.M902074200. Epub 2009 Apr 14. J Biol Chem. 2009. PMID: 19366684 Free PMC article.

5

Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1.

Wang A, Savas U, Stout CD, Johnson EF. Wang A, et al. Among authors: savas u. J Biol Chem. 2011 Feb 18;286(7):5736-43. doi: 10.1074/jbc.M110.204420. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147782 Free PMC article.

6

20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.

Savas Ü, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF. Savas Ü, et al. J Biol Chem. 2016 Aug 5;291(32):16904-19. doi: 10.1074/jbc.M116.732297. Epub 2016 Jun 13. J Biol Chem. 2016. PMID: 27298316 Free PMC article.

7

Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.

Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP. Albertolle ME, et al. Among authors: savas u. J Biol Chem. 2017 Jul 7;292(27):11230-11242. doi: 10.1074/jbc.M117.792200. Epub 2017 May 22. J Biol Chem. 2017. PMID: 28533430 Free PMC article.

8

The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.

Hsu MH, Savas U, Johnson EF. Hsu MH, et al. Among authors: savas u. Mol Pharmacol. 2018 Jan;93(1):14-24. doi: 10.1124/mol.117.109744. Epub 2017 Nov 1. Mol Pharmacol. 2018. PMID: 29093019 Free PMC article.

9

Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells.

Hsu MH, Savas U, Griffin KJ, Johnson EF. Hsu MH, et al. Among authors: savas u. J Biol Chem. 2001 Jul 27;276(30):27950-8. doi: 10.1074/jbc.M100258200. Epub 2001 May 22. J Biol Chem. 2001. PMID: 11371553 Free article.

10

Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone.

Savas U, Hsu MH, Johnson EF. Savas U, et al. Arch Biochem Biophys. 2003 Jan 1;409(1):212-20. doi: 10.1016/s0003-9861(02)00499-x. Arch Biochem Biophys. 2003. PMID: 12464261

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