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Page 1
Engineering of stable bispecific antibodies targeting IL-17A and IL-23.
Mabry R, Lewis KE, Moore M, McKernan PA, Bukowski TR, Bontadelli K, Brender T, Okada S, Lum K, West J, Kuijper JL, Ardourel D, Franke S, Lockwood L, Vu T, Frank A, Appleby MW, Wolf A, Reardon B, Hamacher NB, Stevens B, Lewis P, Lewis KB, Gilbertson DG, Lantry M, Julien SH, Ostrander C, Chan C, Byrnes-Blake K, Brody J, Presnell S, Meengs B, Levin SD, Snavely M. Mabry R, et al. Protein Eng Des Sel. 2010 Mar;23(3):115-27. doi: 10.1093/protein/gzp073. Epub 2009 Dec 18. Protein Eng Des Sel. 2010. PMID: 20022918
A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo.
Mabry R, Gilbertson DG, Frank A, Vu T, Ardourel D, Ostrander C, Stevens B, Julien S, Franke S, Meengs B, Brody J, Presnell S, Hamacher NB, Lantry M, Wolf A, Bukowski T, Rosler R, Yen C, Anderson-Haley M, Brasel K, Pan Q, Franklin H, Thompson P, Dodds M, Underwood S, Peterson S, Sivakumar PV, Snavely M. Mabry R, et al. MAbs. 2010 Jan-Feb;2(1):20-34. doi: 10.4161/mabs.2.1.10498. Epub 2010 Jan 2. MAbs. 2010. PMID: 20065654 Free PMC article.
Vstm3 is a member of the CD28 family and an important modulator of T-cell function.
Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, Chadwick EM, Johnston J, Hammond A, Bontadelli K, Ardourel D, Hebb L, Wolf A, Bukowski TR, Rixon MW, Kuijper JL, Ostrander CD, West JW, Bilsborough J, Fox B, Gao Z, Xu W, Ramsdell F, Blazar BR, Lewis KE. Levin SD, et al. Eur J Immunol. 2011 Apr;41(4):902-15. doi: 10.1002/eji.201041136. Epub 2011 Mar 18. Eur J Immunol. 2011. PMID: 21416464 Free PMC article.
Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody.
Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC, Hamacher NB, Rixon MW, Dillon SR. Lewis KE, et al. Among authors: wolf ac. J Eur Acad Dermatol Venereol. 2017 Jan;31(1):142-150. doi: 10.1111/jdv.13794. Epub 2016 Aug 8. J Eur Acad Dermatol Venereol. 2017. PMID: 27501029
Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons.
Roberts BL, Bennett BJ, Bennett CM, Carroll JM, Dalbøge LS, Hall C, Hassouneh W, Heppner KM, Kirigiti MA, Lindsley SR, Tennant KG, True CA, Whittle A, Wolf AC, Roberts CT Jr, Tang-Christensen M, Sleeman MW, Cowley MA, Grove KL, Kievit P. Roberts BL, et al. Among authors: wolf ac. Mol Metab. 2019 Aug;26:18-29. doi: 10.1016/j.molmet.2019.06.001. Epub 2019 Jun 8. Mol Metab. 2019. PMID: 31230943 Free PMC article.
36 results