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Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence.
Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN. Tavares CD, et al. Biochemistry. 2012 Mar 20;51(11):2232-45. doi: 10.1021/bi201788e. Epub 2012 Mar 6. Biochemistry. 2012. PMID: 22329831 Free PMC article.
The molecular mechanism of eukaryotic elongation factor 2 kinase activation.
Tavares CD, Ferguson SB, Giles DH, Wang Q, Wellmann RM, O'Brien JP, Warthaka M, Brodbelt JS, Ren P, Dalby KN. Tavares CD, et al. J Biol Chem. 2014 Aug 22;289(34):23901-16. doi: 10.1074/jbc.M114.577148. Epub 2014 Jul 10. J Biol Chem. 2014. PMID: 25012662 Free PMC article.
284 results