Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase.
Green LS, Chun LE, Patton AK, Sun X, Rosenthal GJ, Richards JP.
Green LS, et al. Among authors: sun x.
Biochemistry. 2012 Mar 13;51(10):2157-68. doi: 10.1021/bi201785u. Epub 2012 Feb 28.
Biochemistry. 2012.
PMID: 22335564
Inhibition of GSNOR by N6022 and related compounds has shown safety and efficacy in animal models of asthma, chronic obstructive pulmonary disease, and inflammatory bowel disease [Sun, X., et al. (2011) ACS Med. Chem. Lett. 2, 402-406]. N6022 is currently in early p …
Inhibition of GSNOR by N6022 and related compounds has shown safety and efficacy in animal models of asthma, chronic obstructive pulmonary d …