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PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.
Falkowska E, Ramos A, Feng Y, Zhou T, Moquin S, Walker LM, Wu X, Seaman MS, Wrin T, Kwong PD, Wyatt RT, Mascola JR, Poignard P, Burton DR. Falkowska E, et al. Among authors: wrin t. J Virol. 2012 Apr;86(8):4394-403. doi: 10.1128/JVI.06973-11. Epub 2012 Feb 15. J Virol. 2012. PMID: 22345481 Free PMC article.
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.
Labrijn AF, Poignard P, Raja A, Zwick MB, Delgado K, Franti M, Binley J, Vivona V, Grundner C, Huang CC, Venturi M, Petropoulos CJ, Wrin T, Dimitrov DS, Robinson J, Kwong PD, Wyatt RT, Sodroski J, Burton DR. Labrijn AF, et al. Among authors: wrin t. J Virol. 2003 Oct;77(19):10557-65. doi: 10.1128/jvi.77.19.10557-10565.2003. J Virol. 2003. PMID: 12970440 Free PMC article.
Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses.
Deeks SG, Schweighardt B, Wrin T, Galovich J, Hoh R, Sinclair E, Hunt P, McCune JM, Martin JN, Petropoulos CJ, Hecht FM. Deeks SG, et al. Among authors: wrin t. J Virol. 2006 Jun;80(12):6155-64. doi: 10.1128/JVI.00093-06. J Virol. 2006. PMID: 16731954 Free PMC article.
Lack of neutralizing antibody response to HIV-1 predisposes to superinfection.
Smith DM, Strain MC, Frost SD, Pillai SK, Wong JK, Wrin T, Liu Y, Petropolous CJ, Daar ES, Little SJ, Richman DD. Smith DM, et al. Among authors: wrin t. Virology. 2006 Nov 10;355(1):1-5. doi: 10.1016/j.virol.2006.08.009. Epub 2006 Sep 7. Virology. 2006. PMID: 16962152 Free article.
132 results