Schenk G - Search Results

1

Promiscuity comes at a price: catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQ.

Daumann LJ, McCarthy BY, Hadler KS, Murray TP, Gahan LR, Larrabee JA, Ollis DL, Schenk G. Daumann LJ, et al. Among authors: schenk g. Biochim Biophys Acta. 2013 Jan;1834(1):425-32. doi: 10.1016/j.bbapap.2012.02.004. Epub 2012 Feb 15. Biochim Biophys Acta. 2013. PMID: 22366468

2

Cadmium(II) complexes of the glycerophosphodiester-degrading enzyme GpdQ and a biomimetic N,O ligand.

Mirams RE, Smith SJ, Hadler KS, Ollis DL, Schenk G, Gahan LR. Mirams RE, et al. Among authors: schenk g. J Biol Inorg Chem. 2008 Sep;13(7):1065-72. doi: 10.1007/s00775-008-0392-5. Epub 2008 Jun 6. J Biol Inorg Chem. 2008. PMID: 18535849

3

Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference.

Jackson CJ, Hadler KS, Carr PD, Oakley AJ, Yip S, Schenk G, Ollis DL. Jackson CJ, et al. Among authors: schenk g. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Aug 1;64(Pt 8):681-5. doi: 10.1107/S1744309108017600. Epub 2008 Jul 5. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18678932 Free PMC article.

4

Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes.

Hadler KS, Tanifum EA, Yip SH, Mitić N, Guddat LW, Jackson CJ, Gahan LR, Nguyen K, Carr PD, Ollis DL, Hengge AC, Larrabee JA, Schenk G. Hadler KS, et al. Among authors: schenk g. J Am Chem Soc. 2008 Oct 29;130(43):14129-38. doi: 10.1021/ja803346w. Epub 2008 Oct 3. J Am Chem Soc. 2008. PMID: 18831553 Free PMC article.

5

Structural flexibility enhances the reactivity of the bioremediator glycerophosphodiesterase by fine-tuning its mechanism of hydrolysis.

Hadler KS, Mitić N, Ely F, Hanson GR, Gahan LR, Larrabee JA, Ollis DL, Schenk G. Hadler KS, et al. Among authors: schenk g. J Am Chem Soc. 2009 Aug 26;131(33):11900-8. doi: 10.1021/ja903534f. J Am Chem Soc. 2009. PMID: 19653693

6

The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis.

Hadler KS, Gahan LR, Ollis DL, Schenk G. Hadler KS, et al. Among authors: schenk g. J Inorg Biochem. 2010 Feb;104(2):211-3. doi: 10.1016/j.jinorgbio.2009.10.012. Epub 2009 Oct 23. J Inorg Biochem. 2010. PMID: 19923005

7

Electronic structure analysis of the dinuclear metal center in the bioremediator glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes.

Hadler KS, Mitić N, Yip SH, Gahan LR, Ollis DL, Schenk G, Larrabee JA. Hadler KS, et al. Among authors: schenk g. Inorg Chem. 2010 Mar 15;49(6):2727-34. doi: 10.1021/ic901950c. Inorg Chem. 2010. PMID: 20163105

8

The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis.

Mitić N, Hadler KS, Gahan LR, Hengge AC, Schenk G. Mitić N, et al. Among authors: schenk g. J Am Chem Soc. 2010 May 26;132(20):7049-54. doi: 10.1021/ja910583y. J Am Chem Soc. 2010. PMID: 20433174 Free PMC article.

9

The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis.

Ely F, Hadler KS, Gahan LR, Guddat LW, Ollis DL, Schenk G. Ely F, et al. Among authors: schenk g. Biochem J. 2010 Dec 15;432(3):565-73. doi: 10.1042/BJ20101054. Biochem J. 2010. PMID: 20868365

10

Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme.

Yip SH, Foo JL, Schenk G, Gahan LR, Carr PD, Ollis DL. Yip SH, et al. Among authors: schenk g. Protein Eng Des Sel. 2011 Dec;24(12):861-72. doi: 10.1093/protein/gzr048. Epub 2011 Oct 6. Protein Eng Des Sel. 2011. PMID: 21979136

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