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Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.
Sheng XC, Appleby T, Butler T, Cai R, Chen X, Cho A, Clarke MO, Cottell J, Delaney WE 4th, Doerffler E, Link J, Ji M, Pakdaman R, Pyun HJ, Wu Q, Xu J, Kim CU. Sheng XC, et al. Among authors: butler t. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2629-34. doi: 10.1016/j.bmcl.2012.01.017. Epub 2012 Feb 1. Bioorg Med Chem Lett. 2012. PMID: 22366653 Clinical Trial.
Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.
Cho A, Zhang L, Xu J, Lee R, Butler T, Metobo S, Aktoudianakis V, Lew W, Ye H, Clarke M, Doerffler E, Byun D, Wang T, Babusis D, Carey AC, German P, Sauer D, Zhong W, Rossi S, Fenaux M, McHutchison JG, Perry J, Feng J, Ray AS, Kim CU. Cho A, et al. Among authors: butler t. J Med Chem. 2014 Mar 13;57(5):1812-25. doi: 10.1021/jm400201a. Epub 2013 May 1. J Med Chem. 2014. PMID: 23547794
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Kirschberg TA, Metobo S, Clarke MO, Aktoudianakis V, Babusis D, Barauskas O, Birkus G, Butler T, Byun D, Chin G, Doerffler E, Edwards TE, Fenaux M, Lee R, Lew W, Mish MR, Murakami E, Park Y, Squires NH, Tirunagari N, Wang T, Whitcomb M, Xu J, Yang H, Ye H, Zhang L, Appleby TC, Feng JY, Ray AS, Cho A, Kim CU. Kirschberg TA, et al. Among authors: butler t. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1840-1847. doi: 10.1016/j.bmcl.2017.02.037. Epub 2017 Feb 20. Bioorg Med Chem Lett. 2017. PMID: 28274633
Four-electron reduction of benzene by a samarium(II)-alkyl without the addition of external reducing agents.
Richardson GM, Rajeshkumar T, Burke FM, Cameron SA, Nicholls BD, Harvey JE, Keyzers RA, Butler T, Granville S, Liu L, Langley J, Lim LF, Cox N, Chilton NF, Hicks J, Davis NJLK, Maron L, Anker MD. Richardson GM, et al. Among authors: butler t. Nat Chem. 2025 Jan;17(1):20-28. doi: 10.1038/s41557-024-01688-6. Epub 2025 Jan 3. Nat Chem. 2025. PMID: 39754016
Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis.
Khalafi M, Dartora WJ, McIntire LBJ, Butler TA, Wartchow KM, Hojjati SH, Razlighi QR, Shirbandi K, Zhou L, Chen K, Xi K, Banerjee S, Foldi N, Pahlajani S, Glodzik L, Li Y, de Leon MJ, Chiang GC. Khalafi M, et al. Among authors: butler ta. Alzheimers Dement. 2024 Dec 23. doi: 10.1002/alz.14458. Online ahead of print. Alzheimers Dement. 2024. PMID: 39711334 Review.
1,310 results