Gruber JM - Search Results

1

3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity.

Fisher MJ, Backer RT, Barth VN, Garbison KE, Gruber JM, Heinz BA, Iyengar S, Hollinshead SP, Kingston A, Kuklish SL, Li L, Nisenbaum ES, Peters SC, Phebus L, Simmons RM, van der Aar E. Fisher MJ, et al. Among authors: gruber jm. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2514-7. doi: 10.1016/j.bmcl.2012.02.003. Epub 2012 Feb 9. Bioorg Med Chem Lett. 2012. PMID: 22386665

2

Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: design, synthesis, and biological evaluation.

Hamdouchi C, Sanchez-Martinez C, Gruber J, Del Prado M, Lopez J, Rubio A, Heinz BA. Hamdouchi C, et al. J Med Chem. 2003 Sep 25;46(20):4333-41. doi: 10.1021/jm020583i. J Med Chem. 2003. PMID: 13678411

3

Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).

Norman BH, Gruber JM, Hollinshead SP, Wilson JW, Starling JJ, Law KL, Self TD, Tabas LB, Williams DC, Paul DC, Wagner MM, Dantzig AH. Norman BH, et al. Among authors: gruber jm. Bioorg Med Chem Lett. 2002 Mar 25;12(6):883-6. doi: 10.1016/s0960-894x(02)00051-3. Bioorg Med Chem Lett. 2002. PMID: 11958985

4

2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imid azo[1,2-a]pyridines as a novel class of inhibitors of human rhinovirus: stereospecific synthesis and antiviral activity.

Hamdouchi C, de Blas J, del Prado M, Gruber J, Heinz BA, Vance L. Hamdouchi C, et al. J Med Chem. 1999 Jan 14;42(1):50-9. doi: 10.1021/jm9810405. J Med Chem. 1999. PMID: 9888832

5

Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).

Norman BH, Lander PA, Gruber JM, Kroin JS, Cohen JD, Jungheim LN, Starling JJ, Law KL, Self TD, Tabas LB, Williams DC, Paul DC, Dantzig AH. Norman BH, et al. Among authors: gruber jm. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5526-30. doi: 10.1016/j.bmcl.2005.08.075. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202586

6

Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region.

Shih C, Gossett LS, Gruber JM, Grossman CS, Andis SL, Schultz RM, Worzalla JF, Corbett TH, Metz JT. Shih C, et al. Among authors: gruber jm. Bioorg Med Chem Lett. 1999 Jan 4;9(1):69-74. doi: 10.1016/s0960-894x(98)00682-9. Bioorg Med Chem Lett. 1999. PMID: 9990459

7

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.

Jones SB, Pfeifer LA, Bleisch TJ, Beauchamp TJ, Durbin JD, Klimkowski VJ, Hughes NE, Rito CJ, Dao Y, Gruber JM, Bui H, Chambers MG, Chandrasekhar S, Lin C, McCann DJ, Mudra DR, Oskins JL, Swearingen CA, Thirunavukkarasu K, Norman BH. Jones SB, et al. Among authors: gruber jm. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61. doi: 10.1021/acsmedchemlett.6b00207. eCollection 2016 Sep 8. ACS Med Chem Lett. 2016. PMID: 27660691 Free PMC article.

8

Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein.

Starling JJ, Shepard RL, Cao J, Law KL, Norman BH, Kroin JS, Ehlhardt WJ, Baughman TM, Winter MA, Bell MG, Shih C, Gruber J, Elmquist WF, Dantzig AH. Starling JJ, et al. Adv Enzyme Regul. 1997;37:335-47. doi: 10.1016/s0065-2571(96)00021-0. Adv Enzyme Regul. 1997. PMID: 9381979

9

Conformationally restricted retinoids.

Dawson MI, Hobbs PD, Derdzinski K, Chan RL, Gruber J, Chao WR, Smith S, Thies RW, Schiff LJ. Dawson MI, et al. J Med Chem. 1984 Nov;27(11):1516-31. doi: 10.1021/jm00377a022. J Med Chem. 1984. PMID: 6208361

10

Metabolism and disposition of the antifolate LY231514 in mice and dogs.

Woodland JM, Barnett CJ, Dorman DE, Gruber JM, Shih C, Spangle LA, Wilson TM, Ehlhardt WJ. Woodland JM, et al. Among authors: gruber jm. Drug Metab Dispos. 1997 Jun;25(6):693-700. Drug Metab Dispos. 1997. PMID: 9193870

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