Jacobson KA - Search Results

1

Synthesis and P2Y₂ receptor agonist activities of uridine 5'-phosphonate analogues.

Van Poecke S, Barrett MO, Santhosh Kumar T, Sinnaeve D, Martins JC, Jacobson KA, Kendall Harden T, Van Calenbergh S. Van Poecke S, et al. Among authors: jacobson ka. Bioorg Med Chem. 2012 Apr 1;20(7):2304-15. doi: 10.1016/j.bmc.2012.02.012. Epub 2012 Feb 15. Bioorg Med Chem. 2012. PMID: 22386981 Free PMC article.

2

Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

Karton Y, Jiang JL, Ji XD, Melman N, Olah ME, Stiles GL, Jacobson KA. Karton Y, et al. Among authors: jacobson ka. J Med Chem. 1996 Jun 7;39(12):2293-301. doi: 10.1021/jm950923i. J Med Chem. 1996. PMID: 8691424 Free PMC article.

3

Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

Nandanan E, Camaioni E, Jang SY, Kim YC, Cristalli G, Herdewijn P, Secrist JA 3rd, Tiwari KN, Mohanram A, Harden TK, Boyer JL, Jacobson KA. Nandanan E, et al. Among authors: jacobson ka. J Med Chem. 1999 May 6;42(9):1625-38. doi: 10.1021/jm980657j. J Med Chem. 1999. PMID: 10229631 Free PMC article.

4

Characterization of "mini-nucleotides" as P2X receptor agonists in rat cardiomyocyte cultures. An integrated synthetic, biochemical, and theoretical study.

Fischer B, Yefidoff R, Major DT, Rutman-Halili I, Shneyvays V, Zinman T, Jacobson KA, Shainberg A. Fischer B, et al. Among authors: jacobson ka. J Med Chem. 1999 Jul 15;42(14):2685-96. doi: 10.1021/jm990085i. J Med Chem. 1999. PMID: 10411489 Free PMC article.

5

Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists.

Kim YC, Gallo-Rodriguez C, Jang SY, Nandanan E, Adams M, Harden TK, Boyer JL, Jacobson KA. Kim YC, et al. Among authors: jacobson ka. J Med Chem. 2000 Feb 24;43(4):746-55. doi: 10.1021/jm9905211. J Med Chem. 2000. PMID: 10691699 Free PMC article.

6

Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.

Nandanan E, Jang SY, Moro S, Kim HO, Siddiqui MA, Russ P, Marquez VE, Busson R, Herdewijn P, Harden TK, Boyer JL, Jacobson KA. Nandanan E, et al. Among authors: jacobson ka. J Med Chem. 2000 Mar 9;43(5):829-42. doi: 10.1021/jm990249v. J Med Chem. 2000. PMID: 10715151 Free PMC article.

7

Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.

Jacobson KA, Ji X, Li AH, Melman N, Siddiqui MA, Shin KJ, Marquez VE, Ravi RG. Jacobson KA, et al. J Med Chem. 2000 Jun 1;43(11):2196-203. doi: 10.1021/jm9905965. J Med Chem. 2000. PMID: 10841798 Free PMC article.

8

Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.

Jacobson KA, Gao ZG, Chen A, Barak D, Kim SA, Lee K, Link A, Rompaey PV, van Calenbergh S, Liang BT. Jacobson KA, et al. J Med Chem. 2001 Nov 22;44(24):4125-36. doi: 10.1021/jm010232o. J Med Chem. 2001. PMID: 11708915 Free PMC article.

9

Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.

Kim HS, Ravi RG, Marquez VE, Maddileti S, Wihlborg AK, Erlinge D, Malmsjö M, Boyer JL, Harden TK, Jacobson KA. Kim HS, et al. Among authors: jacobson ka. J Med Chem. 2002 Jan 3;45(1):208-18. doi: 10.1021/jm010369e. J Med Chem. 2002. PMID: 11754592 Free PMC article.

10

Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.

Ravi RG, Kim HS, Servos J, Zimmermann H, Lee K, Maddileti S, Boyer JL, Harden TK, Jacobson KA. Ravi RG, et al. Among authors: jacobson ka. J Med Chem. 2002 May 9;45(10):2090-100. doi: 10.1021/jm010538v. J Med Chem. 2002. PMID: 11985476 Free PMC article.

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