Le Hir H - Search Results

1

The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.

Murachelli AG, Ebert J, Basquin C, Le Hir H, Conti E. Murachelli AG, et al. Among authors: le hir h. Nat Struct Mol Biol. 2012 Mar 4;19(4):378-86. doi: 10.1038/nsmb.2242. Nat Struct Mol Biol. 2012. PMID: 22388736

2

A UPF3-mediated regulatory switch that maintains RNA surveillance.

Chan WK, Bhalla AD, Le Hir H, Nguyen LS, Huang L, Gécz J, Wilkinson MF. Chan WK, et al. Among authors: le hir h. Nat Struct Mol Biol. 2009 Jul;16(7):747-53. doi: 10.1038/nsmb.1612. Epub 2009 Jun 7. Nat Struct Mol Biol. 2009. PMID: 19503078

3

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

Buchwald G, Ebert J, Basquin C, Sauliere J, Jayachandran U, Bono F, Le Hir H, Conti E. Buchwald G, et al. Among authors: le hir h. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10050-5. doi: 10.1073/pnas.1000993107. Epub 2010 May 17. Proc Natl Acad Sci U S A. 2010. PMID: 20479275 Free PMC article.

4

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.

Chakrabarti S, Jayachandran U, Bonneau F, Fiorini F, Basquin C, Domcke S, Le Hir H, Conti E. Chakrabarti S, et al. Among authors: le hir h. Mol Cell. 2011 Mar 18;41(6):693-703. doi: 10.1016/j.molcel.2011.02.010. Mol Cell. 2011. PMID: 21419344 Free article.

5

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain.

Buchwald G, Schüssler S, Basquin C, Le Hir H, Conti E. Buchwald G, et al. Among authors: le hir h. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4611-8. doi: 10.1073/pnas.1314684110. Epub 2013 Nov 11. Proc Natl Acad Sci U S A. 2013. PMID: 24218557 Free PMC article.

6

Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes.

Busetto V, Barbosa I, Basquin J, Marquenet É, Hocq R, Hennion M, Paternina JA, Namane A, Conti E, Bensaude O, Le Hir H. Busetto V, et al. Among authors: le hir h. Nucleic Acids Res. 2020 Jun 4;48(10):5670-5683. doi: 10.1093/nar/gkaa267. Nucleic Acids Res. 2020. PMID: 32329775 Free PMC article.

7

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

Ballut L, Marchadier B, Baguet A, Tomasetto C, Séraphin B, Le Hir H. Ballut L, et al. Among authors: le hir h. Nat Struct Mol Biol. 2005 Oct;12(10):861-9. doi: 10.1038/nsmb990. Epub 2005 Sep 18. Nat Struct Mol Biol. 2005. PMID: 16170325

8

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.

Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Séraphin B, Le Hir H, Andersen GR. Andersen CB, et al. Among authors: le hir h. Science. 2006 Sep 29;313(5795):1968-72. doi: 10.1126/science.1131981. Epub 2006 Aug 24. Science. 2006. PMID: 16931718

9

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.

Chamieh H, Ballut L, Bonneau F, Le Hir H. Chamieh H, et al. Among authors: le hir h. Nat Struct Mol Biol. 2008 Jan;15(1):85-93. doi: 10.1038/nsmb1330. Epub 2007 Dec 9. Nat Struct Mol Biol. 2008. PMID: 18066079

10

The exon junction complex differentially marks spliced junctions.

Saulière J, Haque N, Harms S, Barbosa I, Blanchette M, Le Hir H. Saulière J, et al. Among authors: le hir h. Nat Struct Mol Biol. 2010 Oct;17(10):1269-71. doi: 10.1038/nsmb.1890. Epub 2010 Sep 5. Nat Struct Mol Biol. 2010. PMID: 20818392

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