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Atomic view of a toxic amyloid small oligomer.
Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Laganowsky A, et al. Among authors: liu c. Science. 2012 Mar 9;335(6073):1228-31. doi: 10.1126/science.1213151. Science. 2012. PMID: 22403391 Free PMC article.
Toxic fibrillar oligomers of amyloid-β have cross-β structure.
Stroud JC, Liu C, Teng PK, Eisenberg D. Stroud JC, et al. Among authors: liu c. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7717-22. doi: 10.1073/pnas.1203193109. Epub 2012 Apr 30. Proc Natl Acad Sci U S A. 2012. PMID: 22547798 Free PMC article.
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. Liu C, et al. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20913-8. doi: 10.1073/pnas.1218792109. Epub 2012 Dec 3. Proc Natl Acad Sci U S A. 2012. PMID: 23213214 Free PMC article.
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