Woster P - Search Results

1

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.

Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, Casero RA Jr, Marton L, Woster P, Minden MD, Dugas M, Wang JC, Dick JE, Müller-Tidow C, Petrie K, Zelent A. Schenk T, et al. Among authors: woster p. Nat Med. 2012 Mar 11;18(4):605-11. doi: 10.1038/nm.2661. Nat Med. 2012. PMID: 22406747 Free PMC article.

2

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.

Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA Jr. Zhu Q, et al. Amino Acids. 2012 Feb;42(2-3):887-98. doi: 10.1007/s00726-011-1004-1. Epub 2011 Jul 30. Amino Acids. 2012. PMID: 21805138 Free PMC article.

3

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr. Murray-Stewart T, et al. Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19. Amino Acids. 2014. PMID: 23508577 Free PMC article.

4

Recent advances in the development of polyamine analogues as antitumor agents.

Casero RA Jr, Woster PM. Casero RA Jr, et al. J Med Chem. 2009 Aug 13;52(15):4551-73. doi: 10.1021/jm900187v. J Med Chem. 2009. PMID: 19534534 Free PMC article. Review. No abstract available.

5

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.

Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA Jr. Huang Y, et al. Clin Cancer Res. 2009 Dec 1;15(23):7217-28. doi: 10.1158/1078-0432.CCR-09-1293. Epub 2009 Nov 24. Clin Cancer Res. 2009. PMID: 19934284 Free PMC article.

6

Polyamine analogues targeting epigenetic gene regulation.

Huang Y, Marton LJ, Woster PM, Casero RA. Huang Y, et al. Essays Biochem. 2009 Nov 4;46:95-110. doi: 10.1042/bse0460007. Essays Biochem. 2009. PMID: 20095972 Free PMC article. Review.

7

Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.

Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM, Casero RA. Jin L, et al. Biochem J. 2013 Jan 15;449(2):459-68. doi: 10.1042/BJ20121360. Biochem J. 2013. PMID: 23072722 Free PMC article.

8

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.

Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA Jr. Huang Y, et al. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8023-8. doi: 10.1073/pnas.0700720104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463086 Free PMC article.

9

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.

Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA Jr, Woster PM. Hazeldine S, et al. J Med Chem. 2012 Sep 13;55(17):7378-91. doi: 10.1021/jm3002845. Epub 2012 Sep 4. J Med Chem. 2012. PMID: 22876979 Free PMC article.

10

Polyamines and cancer: implications for chemotherapy and chemoprevention.

Nowotarski SL, Woster PM, Casero RA Jr. Nowotarski SL, et al. Expert Rev Mol Med. 2013 Feb 22;15:e3. doi: 10.1017/erm.2013.3. Expert Rev Mol Med. 2013. PMID: 23432971 Free PMC article. Review.

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