Enzymatically inactive U(S)3 protein kinase of Marek's disease virus (MDV) is capable of depolymerizing F-actin but results in accumulation of virions in perinuclear invaginations and reduced virus growth.
Schumacher D, McKinney C, Kaufer BB, Osterrieder N.
Schumacher D, et al. Among authors: osterrieder n.
Virology. 2008 May 25;375(1):37-47. doi: 10.1016/j.virol.2008.01.026. Epub 2008 Mar 4.
Virology. 2008.
PMID: 18304599
Free PMC article.
It was also shown that pU(S)3 is involved in actin stress fiber breakdown [Schumacher, D., Tischer, B. K., Trapp, S., and Osterrieder, N. (2005). Here, we constructed a recombinant virus to test the importance of pU(S)3 kinase activity for MDV replication and its fu …
It was also shown that pU(S)3 is involved in actin stress fiber breakdown [Schumacher, D., Tischer, B. K., Trapp, S., and Osterrieder …