Ostaszewski B - Search Results

1

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia.

Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA. Fu H, et al. Among authors: ostaszewski b. Glia. 2012 May;60(6):993-1003. doi: 10.1002/glia.22331. Epub 2012 Mar 21. Glia. 2012. PMID: 22438044 Free PMC article.

2

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.

Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Hong S, et al. J Neurosci. 2011 Nov 2;31(44):15861-9. doi: 10.1523/JNEUROSCI.3272-11.2011. J Neurosci. 2011. PMID: 22049429 Free PMC article.

3

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ. Hong S, et al. Among authors: ostaszewski bl. Neuron. 2014 Apr 16;82(2):308-19. doi: 10.1016/j.neuron.2014.02.027. Epub 2014 Mar 27. Neuron. 2014. PMID: 24685176 Free PMC article.

4

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Welzel AT, et al. Among authors: ostaszewski bl. Biochemistry. 2014 Jun 24;53(24):3908-21. doi: 10.1021/bi5003053. Biochemistry. 2014. PMID: 24840308 Free PMC article.

5

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.

Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Li S, et al. Among authors: ostaszewski bl. Acta Neuropathol Commun. 2018 Nov 8;6(1):121. doi: 10.1186/s40478-018-0626-x. Acta Neuropathol Commun. 2018. PMID: 30409172 Free PMC article.

6

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Xia W, et al. Among authors: ostaszewski bl. Biochemistry. 1998 Nov 24;37(47):16465-71. doi: 10.1021/bi9816195. Biochemistry. 1998. PMID: 9843412

7

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Among authors: ostaszewski bl. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808

8

An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma.

Liu L, Kwak H, Lawton TL, Jin SX, Meunier AL, Dang Y, Ostaszewski B, Pietras AC, Stern AM, Selkoe DJ. Liu L, et al. Among authors: ostaszewski b. Alzheimers Dement. 2022 Jun;18(6):1186-1202. doi: 10.1002/alz.12457. Epub 2021 Sep 22. Alzheimers Dement. 2022. PMID: 34550630 Free PMC article.

9

Amyloid beta-peptide is produced by cultured cells during normal metabolism.

Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al. Haass C, et al. Among authors: ostaszewski bl. Nature. 1992 Sep 24;359(6393):322-5. doi: 10.1038/359322a0. Nature. 1992. PMID: 1383826

10

Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.

Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Schlossmacher MG, et al. Among authors: ostaszewski bl. Neurobiol Aging. 1992 May-Jun;13(3):421-34. doi: 10.1016/0197-4580(92)90117-g. Neurobiol Aging. 1992. PMID: 1625772

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