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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Eicher T, Cha HJ, Seeger MA, Brandstätter L, El-Delik J, Bohnert JA, Kern WV, Verrey F, Grütter MG, Diederichs K, Pos KM. Eicher T, et al. Among authors: bohnert ja. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5687-92. doi: 10.1073/pnas.1114944109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451937 Free PMC article.
Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS.
Brandstätter L, Sokolova L, Eicher T, Seeger MA, Briand C, Cha HJ, Cernescu M, Bohnert J, Kern WV, Brutschy B, Pos KM. Brandstätter L, et al. Biochim Biophys Acta. 2011 Sep;1808(9):2189-96. doi: 10.1016/j.bbamem.2011.05.009. Epub 2011 May 15. Biochim Biophys Acta. 2011. PMID: 21616055 Free article.
47 results