Lim SP - Search Results

1

2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase.

Dong H, Chang DC, Hua MH, Lim SP, Chionh YH, Hia F, Lee YH, Kukkaro P, Lok SM, Dedon PC, Shi PY. Dong H, et al. Among authors: lim sp. PLoS Pathog. 2012;8(4):e1002642. doi: 10.1371/journal.ppat.1002642. Epub 2012 Apr 5. PLoS Pathog. 2012. PMID: 22496660 Free PMC article.

2

Detection and quantification of flavivirus NS5 methyl-transferase activities.

Lim SP, Bodenreider C, Shi PY. Lim SP, et al. Methods Mol Biol. 2013;1030:249-68. doi: 10.1007/978-1-62703-484-5_20. Methods Mol Biol. 2013. PMID: 23821274

3

Flavivirus RNA methylation.

Dong H, Fink K, Züst R, Lim SP, Qin CF, Shi PY. Dong H, et al. Among authors: lim sp. J Gen Virol. 2014 Apr;95(Pt 4):763-778. doi: 10.1099/vir.0.062208-0. Epub 2014 Jan 31. J Gen Virol. 2014. PMID: 24486628 Review.

4

The dengue virus NS5 protein as a target for drug discovery.

Lim SP, Noble CG, Shi PY. Lim SP, et al. Antiviral Res. 2015 Jul;119:57-67. doi: 10.1016/j.antiviral.2015.04.010. Epub 2015 Apr 24. Antiviral Res. 2015. PMID: 25912817 Review.

5

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

Lim SP, Noble CG, Seh CC, Soh TS, El Sahili A, Chan GK, Lescar J, Arora R, Benson T, Nilar S, Manjunatha U, Wan KF, Dong H, Xie X, Shi PY, Yokokawa F. Lim SP, et al. PLoS Pathog. 2016 Aug 8;12(8):e1005737. doi: 10.1371/journal.ppat.1005737. eCollection 2016 Aug. PLoS Pathog. 2016. PMID: 27500641 Free PMC article.

6

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus.

Chung KY, Dong H, Chao AT, Shi PY, Lescar J, Lim SP. Chung KY, et al. Among authors: lim sp. Virology. 2010 Jun 20;402(1):52-60. doi: 10.1016/j.virol.2010.03.011. Epub 2010 Mar 29. Virology. 2010. PMID: 20350738 Free article.

7

Biochemical and genetic characterization of dengue virus methyltransferase.

Dong H, Chang DC, Xie X, Toh YX, Chung KY, Zou G, Lescar J, Lim SP, Shi PY. Dong H, et al. Among authors: lim sp. Virology. 2010 Sep 30;405(2):568-78. doi: 10.1016/j.virol.2010.06.039. Epub 2010 Jul 23. Virology. 2010. PMID: 20655081 Free article.

8

Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor.

Noble CG, Lim SP, Chen YL, Liew CW, Yap L, Lescar J, Shi PY. Noble CG, et al. Among authors: lim sp. J Virol. 2013 May;87(9):5291-5. doi: 10.1128/JVI.00045-13. Epub 2013 Feb 13. J Virol. 2013. PMID: 23408636 Free PMC article.

9

A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities.

Lim SP, Koh JH, Seh CC, Liew CW, Davidson AD, Chua LS, Chandrasekaran R, Cornvik TC, Shi PY, Lescar J. Lim SP, et al. J Biol Chem. 2013 Oct 25;288(43):31105-14. doi: 10.1074/jbc.M113.508606. Epub 2013 Sep 11. J Biol Chem. 2013. PMID: 24025331 Free PMC article.

10

West Nile virus drug discovery.

Lim SP, Shi PY. Lim SP, et al. Viruses. 2013 Dec 3;5(12):2977-3006. doi: 10.3390/v5122977. Viruses. 2013. PMID: 24300672 Free PMC article. Review.

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