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23 results

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Page 1
A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.
Mak PA, Rao SP, Ping Tan M, Lin X, Chyba J, Tay J, Ng SH, Tan BH, Cherian J, Duraiswamy J, Bifani P, Lim V, Lee BH, Ling Ma N, Beer D, Thayalan P, Kuhen K, Chatterjee A, Supek F, Glynne R, Zheng J, Boshoff HI, Barry CE 3rd, Dick T, Pethe K, Camacho LR. Mak PA, et al. ACS Chem Biol. 2012 Jul 20;7(7):1190-7. doi: 10.1021/cb2004884. Epub 2012 Apr 25. ACS Chem Biol. 2012. PMID: 22500615 Free PMC article.
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WY, Patel V, Beer D, Walker JR, Duraiswamy J, Jiricek J, Keller TH, Chatterjee A, Tan MP, Ujjini M, Rao SP, Camacho L, Bifani P, Mak PA, Ma I, Barnes SW, Chen Z, Plouffe D, Thayalan P, Ng SH, Au M, Lee BH, Tan BH, Ravindran S, Nanjundappa M, Lin X, Goh A, Lakshminarayana SB, Shoen C, Cynamon M, Kreiswirth B, Dartois V, Peters EC, Glynne R, Brenner S, Dick T. Pethe K, et al. Among authors: mak pa. Nat Commun. 2010 Aug 24;1(5):57. doi: 10.1038/ncomms1060. Nat Commun. 2010. PMID: 20975714 Free PMC article.
A cell-level quality control workflow for high-throughput image analysis.
Qiu M, Zhou B, Lo F, Cook S, Chyba J, Quackenbush D, Matzen J, Li Z, Mak PA, Chen K, Zhou Y. Qiu M, et al. Among authors: mak pa. BMC Bioinformatics. 2020 Jul 2;21(1):280. doi: 10.1186/s12859-020-03603-5. BMC Bioinformatics. 2020. PMID: 32615917 Free PMC article.
A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.
White KM, De Jesus P, Chen Z, Abreu P Jr, Barile E, Mak PA, Anderson P, Nguyen QT, Inoue A, Stertz S, Koenig R, Pellecchia M, Palese P, Kuhen K, García-Sastre A, Chanda SK, Shaw ML. White KM, et al. Among authors: mak pa. ACS Infect Dis. 2015 Feb 13;1(2):98-109. doi: 10.1021/id500022h. Epub 2014 Dec 15. ACS Infect Dis. 2015. PMID: 25984567 Free PMC article.
Cellular Ser/Thr-kinase assays using generic peptide substrates.
Adams DG, Wang Y, Mak PA, Chyba J, Shalizi O, Matzen J, Anderson P, Smith TR, Garcia M, Welch GL, Claret EJ, Fink M, Orth AP, Caldwell JS, Brinker A. Adams DG, et al. Among authors: mak pa. Curr Chem Genomics. 2008 May 23;1:54-64. doi: 10.2174/1875397300801010054. Curr Chem Genomics. 2008. PMID: 20161828 Free PMC article.
A biochemical screen for GroEL/GroES inhibitors.
Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E. Johnson SM, et al. Among authors: mak pa. Bioorg Med Chem Lett. 2014 Feb 1;24(3):786-9. doi: 10.1016/j.bmcl.2013.12.100. Epub 2014 Jan 2. Bioorg Med Chem Lett. 2014. PMID: 24418775
The nuclear receptor LXR is a glucose sensor.
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E. Mitro N, et al. Among authors: mak pa. Nature. 2007 Jan 11;445(7124):219-23. doi: 10.1038/nature05449. Epub 2006 Dec 24. Nature. 2007. PMID: 17187055
Structure-guided combination therapy to potently improve the function of mutant CFTRs.
Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, McNamara P, Edelman A, Frenkiel S, Matouk E, Sermet-Gaudelus I, Barnes WG, Lukacs GL. Veit G, et al. Among authors: mak pa. Nat Med. 2018 Nov;24(11):1732-1742. doi: 10.1038/s41591-018-0200-x. Epub 2018 Oct 8. Nat Med. 2018. PMID: 30297908 Free PMC article.
23 results