Hua Y - Search Results

1

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.

Rigo F, Hua Y, Chun SJ, Prakash TP, Krainer AR, Bennett CF. Rigo F, et al. Among authors: hua y. Nat Chem Biol. 2012 Apr 15;8(6):555-61. doi: 10.1038/nchembio.939. Nat Chem Biol. 2012. PMID: 22504300 Free PMC article.

2

Antisense-based therapy for the treatment of spinal muscular atrophy.

Rigo F, Hua Y, Krainer AR, Bennett CF. Rigo F, et al. Among authors: hua y. J Cell Biol. 2012 Oct 1;199(1):21-5. doi: 10.1083/jcb.201207087. J Cell Biol. 2012. PMID: 23027901 Free PMC article.

3

Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates.

Rigo F, Chun SJ, Norris DA, Hung G, Lee S, Matson J, Fey RA, Gaus H, Hua Y, Grundy JS, Krainer AR, Henry SP, Bennett CF. Rigo F, et al. Among authors: hua y. J Pharmacol Exp Ther. 2014 Jul;350(1):46-55. doi: 10.1124/jpet.113.212407. Epub 2014 Apr 30. J Pharmacol Exp Ther. 2014. PMID: 24784568 Free PMC article.

4

Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7.

Staropoli JF, Li H, Chun SJ, Allaire N, Cullen P, Thai A, Fleet CM, Hua Y, Bennett CF, Krainer AR, Kerr D, McCampbell A, Rigo F, Carulli JP. Staropoli JF, et al. Among authors: hua y. Genomics. 2015 Apr;105(4):220-8. doi: 10.1016/j.ygeno.2015.01.007. Epub 2015 Jan 31. Genomics. 2015. PMID: 25645699 Free article.

5

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice.

Sinha R, Kim YJ, Nomakuchi T, Sahashi K, Hua Y, Rigo F, Bennett CF, Krainer AR. Sinha R, et al. Among authors: hua y. Nucleic Acids Res. 2018 Jun 1;46(10):4833-4844. doi: 10.1093/nar/gky249. Nucleic Acids Res. 2018. PMID: 29672717 Free PMC article.

6

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model.

Sheng L, Rigo F, Bennett CF, Krainer AR, Hua Y. Sheng L, et al. Among authors: hua y. Nucleic Acids Res. 2020 Apr 6;48(6):2853-2865. doi: 10.1093/nar/gkaa126. Nucleic Acids Res. 2020. PMID: 32103257 Free PMC article.

7

Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon.

Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR. Hua Y, et al. PLoS Biol. 2007 Apr;5(4):e73. doi: 10.1371/journal.pbio.0050073. PLoS Biol. 2007. PMID: 17355180 Free PMC article.

8

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.

Hua Y, Vickers TA, Okunola HL, Bennett CF, Krainer AR. Hua Y, et al. Am J Hum Genet. 2008 Apr;82(4):834-48. doi: 10.1016/j.ajhg.2008.01.014. Epub 2008 Mar 27. Am J Hum Genet. 2008. PMID: 18371932 Free PMC article.

9

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model.

Hua Y, Sahashi K, Hung G, Rigo F, Passini MA, Bennett CF, Krainer AR. Hua Y, et al. Genes Dev. 2010 Aug 1;24(15):1634-44. doi: 10.1101/gad.1941310. Epub 2010 Jul 12. Genes Dev. 2010. PMID: 20624852 Free PMC article.

10

Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy.

Passini MA, Bu J, Richards AM, Kinnecom C, Sardi SP, Stanek LM, Hua Y, Rigo F, Matson J, Hung G, Kaye EM, Shihabuddin LS, Krainer AR, Bennett CF, Cheng SH. Passini MA, et al. Among authors: hua y. Sci Transl Med. 2011 Mar 2;3(72):72ra18. doi: 10.1126/scitranslmed.3001777. Sci Transl Med. 2011. PMID: 21368223 Free PMC article.

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