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Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.
Imamura M, Nakanishi K, Suzuki T, Ikegai K, Shiraki R, Ogiyama T, Murakami T, Kurosaki E, Noda A, Kobayashi Y, Yokota M, Koide T, Kosakai K, Ohkura Y, Takeuchi M, Tomiyama H, Ohta M. Imamura M, et al. Among authors: shiraki r. Bioorg Med Chem. 2012 May 15;20(10):3263-79. doi: 10.1016/j.bmc.2012.03.051. Epub 2012 Mar 29. Bioorg Med Chem. 2012. PMID: 22507206
Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors.
Onda K, Shiraki R, Ogiyama T, Yokoyama K, Momose K, Katayama N, Orita M, Yamaguchi T, Furutani M, Hamada N, Takeuchi M, Okada M, Ohta M, Tsukamoto S. Onda K, et al. Among authors: shiraki r. Bioorg Med Chem. 2008 Dec 1;16(23):10001-12. doi: 10.1016/j.bmc.2008.10.021. Epub 2008 Oct 12. Bioorg Med Chem. 2008. PMID: 18952447
Discovery and Biological Evaluation of Potent and Orally Active Human 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus.
Koike T, Shiraki R, Sasuga D, Hosaka M, Kawano T, Fukudome H, Kurosawa K, Moritomo A, Mimasu S, Ishii H, Yoshimura S. Koike T, et al. Among authors: shiraki r. Chem Pharm Bull (Tokyo). 2019;67(8):824-838. doi: 10.1248/cpb.c19-00211. Chem Pharm Bull (Tokyo). 2019. PMID: 31366832 Free article.
Total Synthesis of (-)-Verrucarol(1).
Ishihara J, Nonaka R, Terasawa Y, Shiraki R, Yabu K, Kataoka H, Ochiai Y, Tadano Ki KI. Ishihara J, et al. Among authors: shiraki r. J Org Chem. 1998 Apr 17;63(8):2679-2688. doi: 10.1021/jo972309f. J Org Chem. 1998. PMID: 11672137
64 results