El-Kattan A - Search Results

1

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability - considerations for drug development.

Lai Y, Varma M, Feng B, Stephens JC, Kimoto E, El-Kattan A, Ichikawa K, Kikkawa H, Ono C, Suzuki A, Suzuki M, Yamamoto Y, Tremaine L. Lai Y, et al. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):723-43. doi: 10.1517/17425255.2012.678048. Epub 2012 Apr 18. Expert Opin Drug Metab Toxicol. 2012. PMID: 22509796 Review.

2

Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.

Barton HA, Lai Y, Goosen TC, Jones HM, El-Kattan AF, Gosset JR, Lin J, Varma MV. Barton HA, et al. Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):459-72. doi: 10.1517/17425255.2013.759210. Epub 2013 Jan 21. Expert Opin Drug Metab Toxicol. 2013. PMID: 23331046 Review.

3

Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.

Varma MV, El-Kattan AF. Varma MV, et al. J Clin Pharmacol. 2016 Jul;56 Suppl 7:S99-S109. doi: 10.1002/jcph.695. J Clin Pharmacol. 2016. PMID: 27385183 Review.

4

Molecular properties associated with transporter-mediated drug disposition.

Varma MV, Lai Y, El-Kattan AF. Varma MV, et al. Adv Drug Deliv Rev. 2017 Jul 1;116:92-99. doi: 10.1016/j.addr.2017.05.014. Epub 2017 May 26. Adv Drug Deliv Rev. 2017. PMID: 28554577 Review.

5

Navigating Transporter Sciences in Pharmacokinetics Characterization Using the Extended Clearance Classification System.

El-Kattan AF, Varma MVS. El-Kattan AF, et al. Drug Metab Dispos. 2018 May;46(5):729-739. doi: 10.1124/dmd.117.080044. Epub 2018 Mar 1. Drug Metab Dispos. 2018. PMID: 29496721 Review.

6

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.

Varma MV, El-Kattan AF, Feng B, Steyn SJ, Maurer TS, Scott DO, Rodrigues AD, Tremaine LM. Varma MV, et al. Clin Pharmacol Ther. 2017 Jul;102(1):33-36. doi: 10.1002/cpt.595. Epub 2017 Feb 3. Clin Pharmacol Ther. 2017. PMID: 27984654 No abstract available.

7

Targeting intestinal transporters for optimizing oral drug absorption.

Varma MV, Ambler CM, Ullah M, Rotter CJ, Sun H, Litchfield J, Fenner KS, El-Kattan AF. Varma MV, et al. Curr Drug Metab. 2010 Nov;11(9):730-42. doi: 10.2174/138920010794328850. Curr Drug Metab. 2010. PMID: 21189135 Review.

8

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.

Bi YA, Kimoto E, Sevidal S, Jones HM, Barton HA, Kempshall S, Whalen KM, Zhang H, Ji C, Fenner KS, El-Kattan AF, Lai Y. Bi YA, et al. Drug Metab Dispos. 2012 Jun;40(6):1085-92. doi: 10.1124/dmd.111.043489. Epub 2012 Mar 1. Drug Metab Dispos. 2012. PMID: 22381335 Review.

9

Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion.

Varma MV, Chang G, Lai Y, Feng B, El-Kattan AF, Litchfield J, Goosen TC. Varma MV, et al. Drug Metab Dispos. 2012 Aug;40(8):1527-37. doi: 10.1124/dmd.112.044628. Epub 2012 May 11. Drug Metab Dispos. 2012. PMID: 22580868

10

Renal transporters in drug disposition, drug-drug interactions, and nephrotoxicity.

Feng B, El-Kattan AF, Radi ZA. Feng B, et al. Curr Protoc Toxicol. 2012 Aug;Chapter 23:Unit 23.3.1-15. doi: 10.1002/0471140856.tx2303s53. Curr Protoc Toxicol. 2012. PMID: 22896010

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