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The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.
Katsoulotos GP, Qi M, Qi JC, Tanaka K, Hughes WE, Molloy TJ, Adachi R, Stevens RL, Krilis SA. Katsoulotos GP, et al. Among authors: krilis sa. J Biol Chem. 2008 Jan 18;283(3):1610-1621. doi: 10.1074/jbc.M707042200. Epub 2007 Nov 16. J Biol Chem. 2008. PMID: 18024961 Free article.
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function.
Yang Y, Li L, Wong GW, Krilis SA, Madhusudhan MS, Sali A, Stevens RL. Yang Y, et al. Among authors: krilis sa. J Biol Chem. 2002 Jul 12;277(28):25756-74. doi: 10.1074/jbc.M202575200. Epub 2002 Apr 15. J Biol Chem. 2002. PMID: 11956218 Free article.
Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.
Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, Frei SM, Wong GW, Hamadi S, Zhou S, Foster PS, Krilis SA, Stevens RL. Hansbro PM, et al. Among authors: krilis sa. J Biol Chem. 2014 Jun 27;289(26):18214-27. doi: 10.1074/jbc.M114.548594. Epub 2014 May 12. J Biol Chem. 2014. PMID: 24821729 Free PMC article.
Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5.
Stevens RL, McNeil HP, Wensing LA, Shin K, Wong GW, Hansbro PM, Krilis SA. Stevens RL, et al. Among authors: krilis sa. J Biol Chem. 2017 Mar 31;292(13):5392-5404. doi: 10.1074/jbc.M116.773416. Epub 2017 Feb 13. J Biol Chem. 2017. PMID: 28193842 Free PMC article.
Essential role for mast cell tryptase in acute experimental colitis.
Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL. Hamilton MJ, et al. Among authors: krilis sa. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):290-5. doi: 10.1073/pnas.1005758108. Epub 2010 Dec 20. Proc Natl Acad Sci U S A. 2011. PMID: 21173247 Free PMC article.
Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway.
Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingam S, Mellor EA, Katsoulotos G, Li L, Boyce JA, Krilis SA, Stevens RL. Wong GW, et al. Among authors: krilis sa. J Biol Chem. 2002 Nov 1;277(44):41906-15. doi: 10.1074/jbc.M205868200. Epub 2002 Aug 22. J Biol Chem. 2002. PMID: 12194977 Free article.
CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.
Zhou S, Tanaka K, O'Keeffe M, Qi M, El-Assaad F, Weaver JC, Chen G, Weatherall C, Wang Y, Giannakopoulos B, Chen L, Yu D, Hamilton MJ, Wensing LA, Stevens RL, Krilis SA. Zhou S, et al. Among authors: krilis sa. PLoS One. 2016 Mar 16;11(3):e0151638. doi: 10.1371/journal.pone.0151638. eCollection 2016. PLoS One. 2016. PMID: 26982501 Free PMC article.
157 results