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The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schönig K, Bujard H, Mandelkow E, Zhou L, Rune G, Mandelkow EM. Mocanu MM, et al. Among authors: mandelkow em, mandelkow e. J Neurosci. 2008 Jan 16;28(3):737-48. doi: 10.1523/JNEUROSCI.2824-07.2008. J Neurosci. 2008. PMID: 18199773 Free PMC article.
Inhibition of tau aggregation in cell models of tauopathy.
Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E. Khlistunova I, et al. Among authors: mandelkow em, mandelkow e. Curr Alzheimer Res. 2007 Dec;4(5):544-6. doi: 10.2174/156720507783018307. Curr Alzheimer Res. 2007. PMID: 18220518 Review.
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM. Sydow A, et al. Among authors: mandelkow em, mandelkow e. J Neurosci. 2011 Feb 16;31(7):2511-25. doi: 10.1523/JNEUROSCI.5245-10.2011. J Neurosci. 2011. PMID: 21325519 Free PMC article.
Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model.
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM. Sydow A, et al. Among authors: mandelkow em, mandelkow e. J Mol Neurosci. 2011 Nov;45(3):432-7. doi: 10.1007/s12031-011-9604-5. Epub 2011 Aug 6. J Mol Neurosci. 2011. PMID: 21822709
230 results