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Page 1
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.
Thomas HE, Mercer CA, Carnevalli LS, Park J, Andersen JB, Conner EA, Tanaka K, Matsutani T, Iwanami A, Aronow BJ, Manway L, Maira SM, Thorgeirsson SS, Mischel PS, Thomas G, Kozma SC. Thomas HE, et al. Among authors: thomas g. Sci Transl Med. 2012 Jun 20;4(139):139ra84. doi: 10.1126/scitranslmed.3003923. Epub 2012 Apr 25. Sci Transl Med. 2012. PMID: 22539746 Free PMC article.
A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies.
Wise-Draper TM, Moorthy G, Salkeni MA, Karim NA, Thomas HE, Mercer CA, Beg MS, O'Gara S, Olowokure O, Fathallah H, Kozma SC, Thomas G, Rixe O, Desai P, Morris JC. Wise-Draper TM, et al. Among authors: thomas g, thomas he. Target Oncol. 2017 Jun;12(3):323-332. doi: 10.1007/s11523-017-0482-9. Target Oncol. 2017. PMID: 28357727 Free PMC article. Clinical Trial.
Mitochondrial Complex I Activity Is Required for Maximal Autophagy.
Thomas HE, Zhang Y, Stefely JA, Veiga SR, Thomas G, Kozma SC, Mercer CA. Thomas HE, et al. Among authors: thomas g. Cell Rep. 2018 Aug 28;24(9):2404-2417.e8. doi: 10.1016/j.celrep.2018.07.101. Cell Rep. 2018. PMID: 30157433 Free PMC article.
Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.
Stefely JA, Zhang Y, Freiberger EC, Kwiecien NW, Thomas HE, Davis AM, Lowry ND, Vincent CE, Shishkova E, Clark NA, Medvedovic M, Coon JJ, Pagliarini DJ, Mercer CA. Stefely JA, et al. Among authors: thomas he. Autophagy. 2020 Dec;16(12):2219-2237. doi: 10.1080/15548627.2020.1719746. Epub 2020 Feb 2. Autophagy. 2020. PMID: 31971854 Free PMC article.
mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.
Orr-Asman MA, Chu Z, Jiang M, Worley M, LaSance K, Koch SE, Carreira VS, Dahche HM, Plas DR, Komurov K, Qi X, Mercer CA, Anthony LB, Rubinstein J, Thomas HE. Orr-Asman MA, et al. Among authors: thomas he. Mol Cancer Ther. 2017 Nov;16(11):2432-2441. doi: 10.1158/1535-7163.MCT-17-0058. Epub 2017 Sep 1. Mol Cancer Ther. 2017. PMID: 28864682
Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.
Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR. Liu H, et al. Among authors: thomas he. Cell Rep. 2017 Feb 28;18(9):2088-2095. doi: 10.1016/j.celrep.2017.02.022. Cell Rep. 2017. PMID: 28249155 Free PMC article.
253 results