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The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
Gouveia TL, Frangiotti MI, de Brito JM, de Castro Neto EF, Sakata MM, Febba AC, Casarini DE, Amado D, Cavalheiro EA, Almeida SS, Manchini MT, Araújo RC, Silva JA Jr, Naffah-Mazzacoratti Mda G. Gouveia TL, et al. Among authors: frangiotti mi. Neurochem Int. 2012 Jul;61(1):54-62. doi: 10.1016/j.neuint.2012.04.012. Epub 2012 Apr 20. Neurochem Int. 2012. PMID: 22542773
Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus.
Gouveia TL, Scorza FA, Silva MJ, Bandeira Tde A, Perosa SR, Argañaraz GA, Silva Mde P, Araujo TR, Frangiotti MI, Amado D, Cavalheiro EA, Silva JA Jr, Naffah-Mazzacoratti Mda G. Gouveia TL, et al. Among authors: frangiotti mi. Epilepsy Behav. 2011 Jan;20(1):1-5. doi: 10.1016/j.yebeh.2010.10.001. Epub 2010 Dec 3. Epilepsy Behav. 2011. PMID: 21130693
Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy.
Gouveia TL, Scorza FA, Iha HA, Frangiotti MI, Perosa SR, Cavalheiro EA, Silva JA Jr, Feliciano RS, de Almeida AC, Naffah-Mazzacoratti MG. Gouveia TL, et al. Among authors: frangiotti mi. Epilepsy Behav. 2014 Jul;36:68-73. doi: 10.1016/j.yebeh.2014.04.009. Epub 2014 May 24. Epilepsy Behav. 2014. PMID: 24857811