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Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition.
Taylor AM, Preston AJ, Paulk NK, Sutherland H, Keenan CM, Wilson PJ, Wlodarski B, Grompe M, Ranganath LR, Gallagher JA, Jarvis JC. Taylor AM, et al. Among authors: gallagher ja. Osteoarthritis Cartilage. 2012 Aug;20(8):880-6. doi: 10.1016/j.joca.2012.04.013. Epub 2012 Apr 24. Osteoarthritis Cartilage. 2012. PMID: 22542924 Free PMC article.
Development of an in vitro model to investigate joint ochronosis in alkaptonuria.
Tinti L, Taylor AM, Santucci A, Wlodarski B, Wilson PJ, Jarvis JC, Fraser WD, Davidson JS, Ranganath LR, Gallagher JA. Tinti L, et al. Among authors: gallagher ja. Rheumatology (Oxford). 2011 Feb;50(2):271-7. doi: 10.1093/rheumatology/keq246. Epub 2010 Oct 15. Rheumatology (Oxford). 2011. PMID: 20952450
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria.
Hughes JH, Liu K, Plagge A, Wilson PJM, Sutherland H, Norman BP, Hughes AT, Keenan CM, Milan AM, Sakai T, Ranganath LR, Gallagher JA, Bou-Gharios G. Hughes JH, et al. Among authors: gallagher ja. Hum Mol Genet. 2019 Dec 1;28(23):3928-3939. doi: 10.1093/hmg/ddz234. Hum Mol Genet. 2019. PMID: 31600782 Free PMC article.
Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces.
Hughes JH, Keenan CM, Sutherland H, Edwards HR, Wilson PJM, Ranganath LR, Jarvis JC, Bou-Gharios G, Gallagher JA. Hughes JH, et al. Among authors: gallagher ja. Calcif Tissue Int. 2021 Feb;108(2):207-218. doi: 10.1007/s00223-020-00764-6. Epub 2020 Oct 14. Calcif Tissue Int. 2021. PMID: 33057760 Free PMC article.
Acute fatal metabolic complications in alkaptonuria.
Davison AS, Milan AM, Gallagher JA, Ranganath LR. Davison AS, et al. Among authors: gallagher ja. J Inherit Metab Dis. 2016 Mar;39(2):203-10. doi: 10.1007/s10545-015-9902-0. Epub 2015 Nov 23. J Inherit Metab Dis. 2016. PMID: 26596578 Review.
237 results