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Page 1
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.
Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, Foulad D, Zadmehr A, Ahlzadeh GE, Kroeger KM, Tesarfreund M, Lee S, Debinski W, Sareen D, Svendsen CN, Rodriguez R, Lowenstein PR, Castro MG. Candolfi M, et al. Among authors: kroeger km. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20021-6. doi: 10.1073/pnas.1008261107. Epub 2010 Oct 28. Proc Natl Acad Sci U S A. 2010. PMID: 21030678 Free PMC article.
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology.
Larocque D, Sanderson NS, Bergeron J, Curtin JF, Girton J, Wibowo M, Bondale N, Kroeger KM, Yang J, Lacayo LM, Reyes KC, Farrokhi C, Pechnick RN, Castro MG, Lowenstein PR. Larocque D, et al. Among authors: kroeger km. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14443-8. doi: 10.1073/pnas.0913496107. Epub 2010 Jul 26. Proc Natl Acad Sci U S A. 2010. PMID: 20660723 Free PMC article.
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Candolfi M, Kroeger KM, Xiong W, Liu C, Puntel M, Yagiz K, Muhammad AG, Mineharu Y, Foulad D, Wibowo M, Assi H, Baker GJ, Lowenstein PR, Castro MG. Candolfi M, et al. Among authors: kroeger km. Anticancer Agents Med Chem. 2011 Oct;11(8):729-38. doi: 10.2174/187152011797378689. Anticancer Agents Med Chem. 2011. PMID: 21707497 Free PMC article. Review.
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.
Zirger JM, Puntel M, Bergeron J, Wibowo M, Moridzadeh R, Bondale N, Barcia C, Kroeger KM, Liu C, Castro MG, Lowenstein PR. Zirger JM, et al. Among authors: kroeger km. Mol Ther. 2012 Apr;20(4):808-19. doi: 10.1038/mt.2011.243. Epub 2012 Jan 10. Mol Ther. 2012. PMID: 22233583 Free PMC article.
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Puntel M, A K M GM, Farrokhi C, Vanderveen N, Paran C, Appelhans A, Kroeger KM, Salem A, Lacayo L, Pechnick RN, Kelson KR, Kaur S, Kennedy S, Palmer D, Ng P, Liu C, Krasinkiewicz J, Lowenstein PR, Castro MG. Puntel M, et al. Among authors: kroeger km. Toxicol Appl Pharmacol. 2013 May 1;268(3):318-30. doi: 10.1016/j.taap.2013.02.001. Epub 2013 Feb 9. Toxicol Appl Pharmacol. 2013. PMID: 23403069 Free PMC article.
70 results