Chen Y - Search Results

1

Discovery of 3H-imidazo[4,5-b]pyridines as potent c-Met kinase inhibitors: design, synthesis, and biological evaluation.

Chen D, Wang Y, Ma Y, Xiong B, Ai J, Chen Y, Geng M, Shen J. Chen D, et al. Among authors: chen y. ChemMedChem. 2012 Jun;7(6):1057-70. doi: 10.1002/cmdc.201200120. Epub 2012 May 13. ChemMedChem. 2012. PMID: 22581753

2

Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.

Wang Y, Ai J, Wang Y, Chen Y, Wang L, Liu G, Geng M, Zhang A. Wang Y, et al. Among authors: chen y. J Med Chem. 2011 Apr 14;54(7):2127-42. doi: 10.1021/jm101340q. Epub 2011 Mar 15. J Med Chem. 2011. PMID: 21405128

3

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold.

Zhao A, Gao X, Wang Y, Ai J, Wang Y, Chen Y, Geng M, Zhang A. Zhao A, et al. Among authors: chen y. Bioorg Med Chem. 2011 Jul 1;19(13):3906-18. doi: 10.1016/j.bmc.2011.05.038. Epub 2011 May 24. Bioorg Med Chem. 2011. PMID: 21665484

4

Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors.

Zhang D, Zhang X, Ai J, Zhai Y, Liang Z, Wang Y, Chen Y, Li C, Zhao F, Jiang H, Geng M, Luo C, Liu H. Zhang D, et al. Among authors: chen y. Bioorg Med Chem. 2013 Nov 1;21(21):6804-20. doi: 10.1016/j.bmc.2013.07.032. Epub 2013 Jul 31. Bioorg Med Chem. 2013. PMID: 23993328

5

Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells.

He CX, Ai J, Xing WQ, Chen Y, Zhang HT, Huang M, Hu YH, Ding J, Geng MY. He CX, et al. Among authors: chen y. Acta Pharmacol Sin. 2014 Jan;35(1):89-97. doi: 10.1038/aps.2013.125. Epub 2013 Nov 18. Acta Pharmacol Sin. 2014. PMID: 24241352 Free PMC article.

6

Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models.

Ai J, Chen Y, Peng X, Ji Y, Xi Y, Shen Y, Yang X, Su Y, Sun Y, Gao Y, Ma Y, Xiong B, Shen J, Ding J, Geng M. Ai J, et al. Among authors: chen y. Mol Cancer Ther. 2018 Apr;17(4):751-762. doi: 10.1158/1535-7163.MCT-17-0368. Epub 2017 Dec 13. Mol Cancer Ther. 2018. PMID: 29237805

7

MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation.

Zhang Z, Meng T, Yang N, Wang W, Xiong B, Chen Y, Ma L, Shen J, Miao ZH, Ding J. Zhang Z, et al. Among authors: chen y. Int J Cancer. 2011 Jul 1;129(1):214-24. doi: 10.1002/ijc.25661. Epub 2010 Nov 3. Int J Cancer. 2011. PMID: 20830720

8

AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and anti-tumour activity via targeting VEGFR, FGFR and PDGFR.

Zhou Y, Chen Y, Tong L, Xie H, Wen W, Zhang J, Xi Y, Shen Y, Geng M, Wang Y, Jiang H, Luo C, Lin L, Ding J. Zhou Y, et al. Among authors: chen y. J Cell Mol Med. 2012 Oct;16(10):2321-30. doi: 10.1111/j.1582-4934.2012.01541.x. J Cell Mol Med. 2012. PMID: 22304225 Free PMC article.

9

SOMG-833, a novel selective c-MET inhibitor, blocks c-MET-dependent neoplastic effects and exerts antitumor activity.

Zhang HT, Wang L, Ai J, Chen Y, He CX, Ji YC, Huang M, Yang JY, Zhang A, Ding J, Geng MY. Zhang HT, et al. Among authors: chen y. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45. doi: 10.1124/jpet.114.214817. Epub 2014 Apr 16. J Pharmacol Exp Ther. 2014. PMID: 24741075

10

Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities.

Liu Z, Ai J, Peng X, Song Z, Wu K, Zhang J, Yao Q, Chen Y, Ji Y, Yang Y, Geng M, Zhang A. Liu Z, et al. Among authors: chen y. ACS Med Chem Lett. 2014 Feb 8;5(4):304-8. doi: 10.1021/ml400373j. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900831 Free PMC article.

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